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http://dx.doi.org/10.1038/cdd.2013.162 | DOI Listing |
J Intensive Care
April 2016
Mitochondrial Pathophysiology Unit, Department of Clinical Sciences, Lund University, Box 117, 221 00 Lund, Sweden.
Cardiac arrest induces the cessation of cerebral blood flow, which can result in brain damage. The primary intervention to salvage the brain under such a pathological condition is to restore the cerebral blood flow to the ischemic region. Ischemia is defined as a reduction in blood flow to a level that is sufficient to alter normal cellular function.
View Article and Find Full Text PDFCell Death Differ
April 2013
Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons In Ireland, 123 St. Stephen's Green, Dublin, Ireland.
Amyotrophic lateral sclerosis (ALS) is a fatal neurological condition with no cure. Mitochondrial dysfunction, Ca(2+) overloading and local hypoxic/ischemic environments have been implicated in the pathophysiology of ALS and are conditions that may initiate metabolic acidosis in the affected tissue. We tested the hypothesis that acidotoxicity and acid-sensing ion channels (ASICs) are involved in the pathophysiology of ALS.
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