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FAK activity exacerbates disturbed flow-mediated atherosclerosis via VEGFR2-Cbl-NF-κB signaling.
bioRxiv
December 2024
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294.
Atherosclerosis develops at predictable sites in the vasculature where branch points and curvatures create non-laminar disturbed flow. This disturbed flow causes vascular inflammation by increased endothelial cell (EC) barrier permeability and the expression of inflammatory genes such as vascular cell adhesion molecule-1 (VCAM-1). Vascular endothelial growth factor receptor 2 (VEGFR2) is important for flow-induced EC inflammation; however, there are still some gaps in the signaling pathway.
View Article and Find Full Text PDF[Quadricuspid Aortic Valve Diagnosed During Surgery in an Elderly Patient with Aortic Stenosis and Regurgitation:Report of a Case].
Kyobu Geka
November 2024
Department of Cardiovascular Surgery, Fukuoka Red Cross Hospital, Fukuoka, Japan.
We report case details of a quadricuspid aortic valve that was diagnosed during surgery in an 82-yearold male with aortic valve stenosis and regurgitation. He had been treated for heart failure with atrial fibrillation, and aortic valve dysfunction. Sinus rhythm was restored after second catheter ablation for atrial fibrillation.
View Article and Find Full Text PDFA case of small intestinal fixation failure.
BJR Case Rep
November 2024
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
A 77-year-old woman underwent CT to evaluate haematemesis. The images showed that the third part of the duodenum flexed steeply on the right side of the aorta and ran caudally, without crossing anterior to the aorta. The duodenal-jejunal junction and jejunum were located on the patient's right side.
View Article and Find Full Text PDFEmbolic myocardial infarction secondary to marantic endocarditis in a patient with ulcerative colitis: case report.
Eur Heart J Case Rep
December 2024
Departament of Cardiology, Hospital Universitario Reina Sofía, Avenida Menéndez Pidal s/n, 14004 Córdoba, Spain.
Background: Nonbacterial thrombotic endocarditis (NBTE) is an uncommon and often underdiagnosed condition characterized by a state of hypercoagulability. We present a case of a patient with ulcerative colitis who experienced a non-ST-segment elevation myocardial infarction as a rare complication of NBTE.
Case Summary: We report a case of a 16-year-old male with a history of ulcerative colitis who presented to the emergency department with chest pain at rest.
Prosthetic valve infective endocarditis due to Burkholderia pseudomallei: A case report and review of the literature.
Acta Trop
December 2024
Department of Medicine, Cairns Hospital, Cairns, Queensland Australia; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia. Electronic address:
Endocarditis is a very rare complication of Burkholderia pseudomallei infection and prosthetic valve endocarditis rarer still. We present, to our knowledge, the first confirmed Australian case of prosthetic valve endocarditis in a patient with melioidosis. Blood cultures were persistently positive for B.
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