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We examine the concept of medical futility by addressing several questions. Should doctors be attempting treatments that have little likelihood of achieving the goals of medicine? What are the goals of medicine? Can we agree when medical treatment fails to achieve such goals? What should the physician do and not do under such circumstances? Exploring these issues has forced us to revisit the doctor-patient relationship and the relationship of the medical profession to society. Medical futility has both quantitative and qualitative components. We argue that medical futility is the unacceptable likelihood of achieving an effect that the patient has the capacity to appreciate as a benefit. Medicine today has the capacity to achieve a multitude of effects, but none creates a benefit unless the patient has the capacity to appreciate it. In the futility debate wherein some critics have failed or refused to define medical futility, an important area of medicine has been neglected - palliative care - the physician's obligation to alleviate suffering, enhance wellbeing, and support the dignity of the patient at the end of life. To provide a broader perspective we end with a view from Germany.
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http://dx.doi.org/10.1016/B978-0-444-53501-6.00014-7 | DOI Listing |
Acta Anaesthesiol Scand
April 2025
Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Background: Adult intensive care unit (ICU) patients receive many interventions, but few are supported by high-certainty evidence. Randomised clinical trials (RCTs) are essential for trustworthy comparisons of intervention effects, but conventional RCTs are costly, cumbersome, inflexible, and often turn out inconclusive. Adaptive platform trials may mitigate these issues and have higher probabilities of obtaining conclusive results faster and at lower costs per participant.
View Article and Find Full Text PDFNurs Crit Care
March 2025
Department of Internal Medicine Nursing, Bursa Uludag University Faculty of Health Sciences, Bursa, Türkiye.
Background: Intensive care units (ICUs) are high-stress environments where nurses frequently encounter futile treatments. These experiences can lead to compassion fatigue (CF) and increase turnover intention (TI) among ICU nurses.
Aim: To examine the levels of attitudes towards futile treatment (ATFT), CF and TI among ICU nurses, to explore their relationship and identify the factors influencing ATFT.
Gynecol Oncol
March 2025
Memorial Sloan Kettering Cancer Center, New York, NY, United States of America. Electronic address:
Introduction: We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC).
Methods: In this phase II/III trial, EC patients with chemotherapy-naïve stage III/IVA (with measurable disease) and stage IVB or recurrent (with or without measurable disease) disease were randomly assigned to PC/metformin (850 mg BID) versus PC/placebo. Metformin or placebo was continued as maintenance therapy after completion of PC until disease progression.
Ann Surg Oncol
March 2025
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Background: Gallbladder cancer (GBC) has a poor prognosis, particularly in advanced stages, with surgery often offering limited survival benefit. This study aimed to identify risk factors for futile surgery (FS), defined as procedures followed by early recurrence or death.
Methods: An international cohort of 788 patients who underwent up-front GBC surgery across 18 centers was analyzed.
Pharm Stat
March 2025
Villanova University, Villanova, Pennsylvania, USA.
Project FrontRunner encourages development of cancer drugs for advanced or metastatic disease in an earlier clinical setting by promoting regulatory approaches such as the accelerated approval pathway. The FDA draft guideline proposes a one-trial approach to combine accelerated approval and regular approval in a single trial to maintain efficiency. This article describes our idea of controlling Type I error for accelerated and regular approvals in the one-trial approach.
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