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Ferroptosis: A Targetable Vulnerability for Melanoma Treatment.
J Invest Dermatol
January 2025
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, China; Furong Laboratory, Changsha, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China. Electronic address:
Melanoma is a devastating form of skin cancer characterized by a high mutational burden, limited treatment success, and dismal prognosis. Although immunotherapy and targeted therapies have significantly revolutionized melanoma treatment, the majority of patients fail to achieve durable responses, highlighting the urgent need for novel therapeutic strategies. Ferroptosis, an iron-dependent form of regulated cell death driven by the overwhelming accumulation of lipid peroxides, has emerged as a promising therapeutic approach in preclinical melanoma models.
View Article and Find Full Text PDFThe European honey buzzard (Pernis apivorus) as an ally for the control of the invasive yellow-legged hornet (Vespa velutina nigrithorax).
Pest Manag Sci
January 2025
Forest Ecology and Restoration Group (FORECO), Departamento de Ciencias de la Vida, Universidad de Alcalá, Madrid, Spain.
Background: Biological control in integrated pest management (IPM) often overlooked avian predators until the emergence of the ecosystem services approach. Birds are now recognized as key regulators of pest populations in agroforestry landscapes due to their high mobility. The invasive yellow-legged hornet, introduced into Europe in 2004, threatens agriculture, beekeeping and native pollinators.
View Article and Find Full Text PDFContemporary Management of the Aortic Valve-Narrative Review of an Evolving Landscape.
J Clin Med
December 2024
Division of Cardiothoracic Surgery, Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Bronx, NY 10467, USA.
Aortic valve replacement has undergone novel changes in recent decades, providing not only a multitude of procedural options but expanding the treatable patient population. Specifically, a number of minimally invasive and interventional treatment options have allowed for the treatment of high and prohibitive risk surgical patients. Further, technology is allowing for the development of innovative surgical and transcatheter valve models, which will advance the treatment of aortic valve disease in the future.
View Article and Find Full Text PDFIntelligent Sensor Software for Robust and Energy-Sustainable Decision-Making in Welding of Steel Reinforcement for Concrete.
Sensors (Basel)
December 2024
PSYCOTRIP Group, Department of Mathematics and Computation, University of La Rioja, 26006 Logroño, Spain.
In today's industrial landscape, optimizing energy consumption, reducing production times, and maintaining quality standards are critical challenges, particularly in energy-intensive processes like resistance spot welding (RSW). This study introduces an intelligent decision support system designed to optimize the RSW process for steel reinforcement bars. By creating robust machine learning models trained on limited datasets, the system generates interactive heat maps that provide real-time guidance to production engineers or intelligent systems, enabling dynamic adaptation to changing conditions and external factors such as fluctuating energy costs.
View Article and Find Full Text PDFGlobal Literature Analysis of Tumor Organoid and Tumor-on-Chip Research.
Cancers (Basel)
January 2025
Hybrid Technology Hub, Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, 0372 Oslo, Norway.
: Tumor organoid and tumor-on-chip (ToC) platforms replicate aspects of the anatomical and physiological states of tumors. They, therefore, serve as models for investigating tumor microenvironments, metastasis, and immune interactions, especially for precision drug testing. To map the changing research diversity and focus in this field, we performed a quality-controlled text analysis of categorized academic publications and clinical studies.
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