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CARD domains mediate anti-phage defence in bacterial gasdermin systems.
Nature
January 2025
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Caspase recruitment domains (CARDs) and pyrin domains are important facilitators of inflammasome activity and pyroptosis. Following pathogen recognition by nucleotide binding-domain, leucine-rich, repeat-containing (NLR) proteins, CARDs recruit and activate caspases, which, in turn, activate gasdermin pore-forming proteins to induce pyroptotic cell death. Here we show that CARD domains are present in defence systems that protect bacteria against phage.
View Article and Find Full Text PDFUrine exosome biomarkers of obesity after Lekhana Basti treatment - Report of a pilot study.
J Ayurveda Integr Med
January 2025
Center for Clinical Research and Education, The University of Trans-Disciplinary Health Sciences and Technology, Bangalore, India; Internal Medicine - Cardiology, University of Michigan, Ann Arbor, MI, USA. Electronic address:
Background: Obesity is a rising risk factor for various diseases including cardiovascular diseases and Cancer. The limitations of targeted obesity-treatment approaches employed in the clinic presently underscore the importance of developing integrative management strategies for identification of specific biomarkers of obesity.
Objectives: Given the specificity of exosome/extracellular vesicle (EV) biomarkers, we aimed here to identify the EV biomarkers of Ayurveda treatment - Lekhana Basti - for Obesity.
Revealing mitochondrial architecture and functions with single molecule localization microscopy.
Biol Cell
January 2025
CNRS, Univ Rennes, IGDR [(Institut de Génétique et Développement de Rennes)]-UMR 6290, Rennes, France.
Understanding the spatiotemporal organization of components within living systems requires the highest resolution possible. Microscopy approaches that allow for a resolution below 250 nm include electron and super-resolution microscopy (SRM). The latter combines advanced imaging techniques and the optimization of image processing methods.
View Article and Find Full Text PDFDeciphering cellular complexity: advances and future directions in single-cell protein analysis.
Front Bioeng Biotechnol
January 2025
Yunnan Key Laboratory of Cell Metabolism and Diseases, Yunnan University, Kunming, China.
Single-cell protein analysis has emerged as a powerful tool for understanding cellular heterogeneity and deciphering the complex mechanisms governing cellular function and fate. This review provides a comprehensive examination of the latest methodologies, including sophisticated cell isolation techniques (Fluorescence-Activated Cell Sorting (FACS), Magnetic-Activated Cell Sorting (MACS), Laser Capture Microdissection (LCM), manual cell picking, and microfluidics) and advanced approaches for protein profiling and protein-protein interaction analysis. The unique strengths, limitations, and opportunities of each method are discussed, along with their contributions to unraveling gene regulatory networks, cellular states, and disease mechanisms.
View Article and Find Full Text PDFScreening of key genes related to autophagy in psoriasis based on gene expression profiling.
Postepy Dermatol Alergol
December 2024
Department of Clinical Laboratory, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Introduction: Autophagy is necessary for the progression of psoriasis.
Aim: This study aimed to recognize possible autophagy-related genes in psoriasis via bioinformatics study to present a better standard for the clinical treatment and management of psoriasis.
Material And Methods: The GEO dataset was utilized to derive the mRNA expression profile of the database GSE78097.
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