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In-vivo and in-vitro assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery.
Daru
December 2024
Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, POB 11795, Egypt.
Background: Bile salts enriched nanovesicles (bilosomes) have been attention worthy in the past few years due to their distinctive effect on the enhancement of drug delivery through various physiological administration routes. Oral delivery of multifunctioning phytochemical curcumin has faced a lot of difficulties due to its scarce solubility and poor oral bioavailability.
Objective: The current investigation aimed to develop curcumin loaded bilosomes for improvement of oral curcumin bioavailability with maximum efficiency and safety.
NK cells-derived extracellular vesicles potency in the B cell lymphoma biotherapy.
Front Immunol
December 2024
Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Introduction: Extracellular vesicles of Natural Killer cells (NKEV) exert an antitumor effect towards hematopoietic and solid tumors and have an immune modulating effect, suggesting a promising role in immune and biotherapy. In this study, a continuation of our former works, we demonstrated a network by mass spectrometry analysis between NKEV protein cargo and antitumor effects. Human healthy NKEV, both exosomes and microvesicles, have a significant and direct cytotoxic effect against human B cell lymphoma in and conditions.
View Article and Find Full Text PDFExosomes of different cellular origins: prospects and challenges in the treatment of acute lung injury after burns.
J Mater Chem B
December 2024
Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Acute lung injury (ALI) is a critical clinical disease caused by direct factors (inhalation injury, gastroesophageal reflux, ) or indirect factors (including infection, sepsis, burn, shock, trauma, acute pancreatitis, fat embolism, drug overdose, ). ALI is characterized mainly by diffuse interstitial and alveolar edema caused by an uncontrolled inflammatory response and damage to the alveoli-capillary barrier and has very high morbidity and mortality rates. Currently, there is no effective treatment strategy other than mechanical ventilation, fluid management or other supportive treatments.
View Article and Find Full Text PDFMetabolomic analysis of plant-derived nanovesicles and extracellular vesicles from Pinellia ternata: insights into a temporary immersion bioreactor system.
Physiol Plant
December 2024
School of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, China.
Plant-derived nanovesicles (PDNVs) and extracellular vesicles (EVs) represent a promising area of research due to their unique properties and potential therapeutic applications. Pinellia ternata (P. ternata) is well-known for its pharmacological properties but the PDNVs and EVs derived from it have been largely understudied.
View Article and Find Full Text PDFExosome Isolation from Pericardial Fluids.
Methods Mol Biol
December 2024
Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Extracellular vehicles such as exosomes which lie in the size range of 30-150 nm have gained significant attention due to their ability to contain molecular cargoes. These vesicles are released by various cells and are found to stably carry their molecular cargoes to recipient cells via different biological fluids. Therefore, exosomes isolated from various fluids such as plasma, urine, and pericardial fluid have been extensively studied in recent years.
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