We report an efficient continuous-wave (CW) and passively Q-switched dual-wavelength Nd:LuLiF4 laser at 1314 and 1321 nm for the first time. Maximum CW output power of 6.08 W is obtained, giving an optical-to-optical conversion efficiency of 30.2% and a slope efficiency of 32.1%. Even using high doping V3+:YAG as the saturable absorber to passively Q-switch the laser, stable dual-wavelength operation remains. Maximum pulse energy extracted from the resonator is 108.7 μJ at 17.2 kHz pulse-repetition rate, and maximum peak power is 885 W.
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http://dx.doi.org/10.1364/OL.38.004425 | DOI Listing |
Hum Gene Ther
December 2024
Prevail Therapeutics, New York, New York, USA.
Recombinant adeno-associated virus (AAV) is one of the main viral vector-based gene therapy platforms. AAV is a virus consisting of a ≈25 nm diameter capsid with a ≈4.7 kb cargo capacity.
View Article and Find Full Text PDFLaser Photon Rev
October 2024
Harvard Medical School, Boston, MA 02114, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Cardiology, Erasmus Medical Center, Rotterdam GD3015, The Netherlands; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Photoacoustic microscopy (PAM) is a high-resolution and non-invasive imaging modality that provides optical absorption contrast. By employing dual- or multiple-wavelength excitation, PAM extends its capabilities to offer valuable spectroscopic information. To achieve efficient multispectral PAM imaging, an essential requirement is a light source characterized by a high repetition rate and switching rate, a ≈microjoule pulse energy, and a ≈nanosecond pulse duration.
View Article and Find Full Text PDFDermatol Surg
December 2024
Dermatology, Weill Cornell Medical School, Private Practice, New York City; New York.
J Cereb Blood Flow Metab
December 2024
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY, USA.
Alzheimer's disease (AD), a neurodegenerative disorder with progressive cognitive decline, remains clinically challenging with limited understanding of etiology and interventions. Clinical studies have reported vascular defects prior to other pathological manifestations of AD, leading to the "Vascular Hypothesis" for the disorder. However, assessments of cerebral vasculature in AD rodent models have been constrained by limited spatiotemporal resolution or field of view of conventional imaging.
View Article and Find Full Text PDFDalton Trans
December 2024
Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okólna 2, 50-422 Wroclaw, Poland.
Efficient and promising luminescent borate glass doped with tin was fabricated and examined. This unique optical material is characterized by two considerably different Sn emission centers affected by distinct crystal field strengths. Firstly, the efficient broadband luminescence can be selectively excited at 266 nm and 360 nm; however, simultaneous activation of both blue and red emission bands is possible as a result of the overlapping of PLE spectra.
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