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Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis.
Elife
January 2025
Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-I to assemble new fibrils. Endogenous collagen production was not required for fibrillogenesis if exogenous collagen was available, but the circadian-regulated vacuolar protein sorting (VPS) 33b and collagen-binding integrin α11 subunit were crucial to fibrillogenesis.
View Article and Find Full Text PDFAerosol CVD Carbon Nanotube Thin Films: From Synthesis to Advanced Applications: A Comprehensive Review.
Adv Mater
January 2025
Department of Nano Engineering, Department of Nano Science and Technology, Sungkyunkwan University Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Seobu-ro 2066, Jangan-gu, Suwon, 16419, Republic of Korea.
Carbon nanotubes (CNTs) produced by the floating-catalyst chemical vapor deposition (FCCVD) method are among the most promising nanomaterials of today, attracting interest from both academic and industrial sectors. These CNTs exhibit exceptional electrical conductivity, optical properties, and mechanical resilience due to their binder-free and low-defect structure, while the FCCVD method enables their continuous and scalable synthesis. Among the methodological FCCVD variations, aerosol CVD' is distinguished by its production of freestanding thin films comprising macroscale CNT networks, which exhibit superior performance and practical applicability.
View Article and Find Full Text PDFPerspectives, Experiences, and Opportunities of Academic Surgeons in the Era of Healthcare Corporatization.
Ann Surg
January 2025
Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Objective: To characterize contemporary surgeons' viewpoints and perspectives on the academic mission during healthcare corporatization.
Summary Background Data: Academic surgery, traditionally driven by the tripartite missions of excellence in clinical care, scientific research, and education, faces increasing challenges from a corporatized healthcare environment. While previous studies have addressed the financial aspects of corporatization, a comprehensive evaluation of academic surgeons' attitudes and experiences remains lacking.
Microbial amidases: Characterization, advances and biotechnological applications.
Biotechnol Notes
December 2024
Centre for Molecular Biology, Central University of Jammu, Rahya Suchani (Bagla), Jammu & Kashmir, India.
The amidases (EC 3.5.1.
View Article and Find Full Text PDFRacial and Ethnic Disparity in the Administration of General Anesthesia.
Anesth Crit Care
October 2024
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
Healthcare disparities continue to affect communities in the United States that are racially and ethnically diverse, disabled, and economically disadvantaged, even though medical and technological advancements have made great strides in these areas. Disparities in health outcomes and difficulties obtaining care for both acute and chronic illnesses are more common among these populations when compared to the overall population. Disparities in anesthesia care delivery have been documented in multiple studies, and they are based on factors such as patients' racial/ethnic background, gender, sexual orientation, ability to communicate in English, and accessibility to health insurance.
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