AI Article Synopsis
- A new needle-type device was created to efficiently prepare and analyze very volatile organic compounds (VVOCs) in gas samples using gas chromatography-mass spectrometry (GC-MS).
- The device utilized two types of activated carbon sorbents and demonstrated effective extraction and desorption of various VVOCs, such as acetaldehyde and ethanol.
- It was found that sample humidity affected only one type of sorbent, while the double-bed extraction needle remained unaffected, leading to successful analysis of VVOCs from healthy subjects' breath.
Article Abstract
A novel needle-type sample preparation device was developed for the determination of very volatile organic compounds (VVOCs) in gaseous samples by gas chromatography-mass spectrometry (GC-MS). Two types of activated-carbon-based sorbents, Carbopack X and a carbon molecular sieve (CMS), were investigated as the extraction medium. A double-bed-type extraction needle showed successful extraction and desorption performance for all investigated VVOCs, including acetaldehyde, isoprene, pentane, acetone, and ethanol. Sensitive and reliable determination of VVOCs was achieved by systematically optimizing several desorption conditions. In addition, the effects of sample humidity on the extraction and desorption of analytes were investigated with the needle-type extraction devices. Only the CMS packed extraction needle was adversely affected by sample humidity during the desorption process; on the other hand the double-bed-type extraction needle was unaffected by sample humidity. Finally, the developed double-bed-type extraction needle was successfully applied to the analysis of breath VVOCs of healthy subjects.
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| http://dx.doi.org/10.1016/j.jpba.2013.09.028 | DOI Listing |
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