Objective: The primary purpose of this study was to establish normative for 18 parameters of Motor Speech Profile (MSP; Computerized Speech Lab; KayPENTAX, Lincoln Park, NJ) in Indian population, specifically for Kannada-speaking adults across age and gender.
Study Design: Cross-sectional study.
Method: Native Kannada speakers (n = 300) were divided into three age groups (20-40, 41-50, and 51-60 years) with 50 males and 50 females in each group. The obtained data are reported across age and gender for the parameters of diadochokinetic rate, second formant transition, and voice and tremor characteristics of MSP software.
Results: Across gender, a statistically significant difference (P < 0.05) was seen for seven parameters; whereas across age, a statistically significant variation was seen for nine parameters in the age group of 51-60 years than other groups (20-40 and 41-50 years).
Conclusion: Establishment of the normative is essential for the effective use of acoustic analysis as an objective tool. The findings of the present study serve as a norm-based reference for MSP software in Indian population, aged between 20 and 60 years.
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http://dx.doi.org/10.1016/j.jvoice.2013.06.009 | DOI Listing |
PLoS One
January 2025
Department of Nursing and Physiotherapy, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Spain.
Background: Motor imagery is the mental representation of a movement without physical execution. When motor imagery is performed to enhance motor learning and performance, participants must reach a temporal congruence between the imagined and actual movement execution. Identifying factors that can influence this capacity could enhance the effectiveness of motor imagery programs.
View Article and Find Full Text PDFPaediatr Drugs
January 2025
Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
Oral ganaxolone (ZTALMY), a synthetic analogue of the endogenous neuroactive steroid allopregnanolone, acts as a positive allosteric modulator of synaptic and extra-synaptic γ-aminobutyric acid (GABA) type A receptor function in the CNS. In the EU and the UK, it is approved for the adjunctive treatment of epileptic seizures associated with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) in patients aged 2-17 years. In a multinational phase III study (Marigold), 17 weeks' therapy with adjunctive ganaxolone, administered orally three times daily with food, significantly reduced 28-day major motor seizure frequency from baseline versus placebo in patients aged 2-19 years with CDD-associated refractory epilepsy.
View Article and Find Full Text PDFNeuroimage
January 2025
Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan. Electronic address:
In recent decades, converging evidence has reached a consensus that human speech production is carried out by large-scale hierarchical network comprising both language-selective and domain-general systems. However, it remains unclear how these systems interact during speech production and the specific contributions of their component regions. By utilizing a series of meta-analytic approaches based on various language tasks, we dissociated four major systems in this study: domain-general, high-level language, motor-perception, and speech-control systems in this study.
View Article and Find Full Text PDFObjectives: The current gold standard for immunofluorescent (IF) visualization of neuromuscular junctions (NMJs) in muscle utilizes frozen tissue sections with fluorescent conjugated antibodies to demarcate neurons and IF alpha-bungarotoxin (α-BTX) to demarcate motor endplates. Frozen tissue sectioning comes with inherent inescapable limitations, including cryosectioning artifact and limited sample shelf-life. However, a parallel approach to identify NMJs in paraffin-embedded tissue sections has not been previously described.
View Article and Find Full Text PDFZhonghua Yi Xue Yi Chuan Xue Za Zhi
January 2025
Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, Henan 450018, China.
Objective: To explore the clinical features of a child with Lamb-Shaffer syndrome (LAMSHF) due to a variant of SOX5 gene.
Methods: A child who was admitted to Children's Hospital Affiliated to Zhengzhou University in July 2022 was selected as the study subject. Clinical data of the child was collected.
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