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Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature. | LitMetric

Long-Term Survival and Improved Quality of Life following Multiple Repeat Gamma Knife Radiosurgeries for Recurrent Glioblastoma Multiforme: A Case Report and Review of the Literature.

Case Rep Oncol Med

Gamma Knife of Spokane, Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USA ; Cancer Care Northwest, 910 W 5th Avenue, Suite 102, Spokane, WA 99204, USA ; University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA.

Published: October 2013

AI Article Synopsis

  • Managing glioblastoma multiforme (GBM) necessitates personalized treatment plans aimed at extending survival and enhancing quality of life, but outcomes are generally poor despite new therapies.
  • This case study illustrates how three sequential Gamma Knife Radiosurgery (GKRS) treatments can significantly improve survival (over four years post-diagnosis) and quality of life for a patient unable to undergo further chemotherapy or aggressive surgery.
  • The report suggests that aggressive local treatment with GKRS at the recurrence stage may be beneficial for certain patients, contributing to better life expectancy and overall well-being.

Article Abstract

The management of glioblastoma multiforme (GBM) is in most cases complex and must be specifically tailored to the needs of the patient with the goals of extended survival and improved quality of life. Despite advancements in therapy, treatment outcomes remain almost universally poor. Salvage treatment options for the recurrence of the disease is an area of intense study. The following case highlights the utility of Gamma Knife Radiosurgery (GKRS) as a salvage treatment. In this clinical situation, three sequential GKRS treatments led to prolonged survival (beyond four years after diagnosis) and improved quality of life in a patient who was unable to receive further chemotherapy regimens and was unwilling to undergo further aggressive resection. To date, there have been few reports of three or more sequential GKRS treatment sessions utilized as salvage therapy for recurrent GBM in patients who can no longer tolerate chemotherapy. This report provides evidence that aggressive local treatment with GKRS at the time of recurrence may be appropriate, depending on a patient's individual clinical situation, and can lead to prolonged survival and improved quality of life.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794517PMC
http://dx.doi.org/10.1155/2013/431857DOI Listing

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