Serum interferon production induced by poly I : C and tilorone and their radioprotective effect in mice exposed to He-alpha particles was studied. The results were compared to those observed after exposure of mice to acute 60Co-gamma irradiation. Interferon production induced by poly I : C was depressed by He-alpha irradiation less than that induced by tilorone. Treatment of mice with poly I : C or tilorone before He-alpha irradiation had no effect on the mortality of animals in contrast to the radioprotective activity of these compounds against 60Co-gamma irradiation.
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