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http://dx.doi.org/10.1104/pp.113.227660 | DOI Listing |
J Prev Alzheimers Dis
January 2025
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
Background: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
Org Lett
January 2025
Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Highly fluorinated naphthyl aldehyde and binaphthyl aldehyde ()- were designed and synthesized for fluorous-phase-based sensing. Greatly enhanced sensitivity and chemoselectivity in going from to ()- in the fluorescent detection of cysteine has been discovered. This is attributed to the increased structural rigidity of the axially chiral binaphthyl unit in ()- upon reaction with cysteine to form the corresponding thiazolidine product.
View Article and Find Full Text PDFPlast Surg (Oakv)
January 2025
Division of Plastic Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada.
Introduction: Every industry has greenhouse gas emissions, with healthcare a significant contributor. In Canada, the healthcare sector is directly and indirectly responsible for 4.6% of the country's greenhouse gas emissions.
View Article and Find Full Text PDFSmall
December 2024
Department of Electrical and Electronic Engineering, Engineering Building A, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
Plasmonic catalysis, whereby either an optically resonating metal couples to a catalytic material or a catalytic metal particle achieves optical resonance, has been a mainstay of photo-catalysis research for the past few decades. However, a new field of metal-dielectric metamaterials, including plasmonic metamaterials, is emerging as the next frontier in catalysis research. With new optical behaviors that can be achieved by sub-wavelength structures, in either periodic or semi-periodic arrangements, metamaterials can overcome some of the limitations of conventional plasmonic catalysis.
View Article and Find Full Text PDFBMC Nutr
December 2024
Department of Food Science and Postharvest Technology, Faculty of Agriculture and Environment, Gulu University, P.O. Box 166, Gulu, Uganda.
Background: Globally, iron deficiency anaemia is a widespread public health problem affecting vulnerable populations including adolescents. However, over the years, the Uganda Demographic Health Surveys mostly report the status of anaemia for women of reproductive age (15-49 years) and children up to 5 years, leaving out the focus on adolescents. Moreover, high prevalence of anaemia among children below five years could suggest that anaemia still persists at adolescence.
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