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Purpose: In this study, we aimed to determine the early results of selective laser trabeculoplasty to trabeculo-Descemet membrane in patients resistant to deep sclerectomy (DS) surgery.
Methods: Twelve eyes of 12 patients that had undergone DS for primary open-angle glaucoma were enrolled. Preoperative and postoperative intraocular pressures (IOP) were measured by Goldmann applanation tonometer. Time to failure after DS was noted. Failure is described as IOP higher than 20 mm Hg. All patients underwent selective laser trabeculoplasty (SLT) after failure. Eight to 10 applications of SLT were applied over the trabeculo-Descemet membrane. Laser was applied to the surgical site only. The IOPs before SLT, at postoperative first week, first month, and third month were measured.
Results: Mean follow-up time was 23.5 ± 9.5 months. Mean preoperative IOP was 34.2 ± 6.7 mm Hg; mean postoperative IOP at first week was 12.7 ± 3.2 mm Hg. Mean time to failure after DS procedure was 21.6 ± 7.6 months. Mean IOP was 20.6 ± 1.9 mm Hg just before SLT procedure. Mean IOP measurements after SLT at first week, first month, and third month were 10.5 ± 2.2 mm Hg, 10.5 ± 1.9 mm Hg, and 10.9 ± 2.1 mm Hg, respectively.
Conclusions: Selective laser trabeculoplasty after DS is an effective and noninvasive procedure that can be done on an outpatient basis. Our results suggest that SLT applied to the surgical site is an effective intervention in the short term but long-term results are required to assess the efficacy.
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http://dx.doi.org/10.5301/ejo.5000383 | DOI Listing |
Drug Deliv Transl Res
December 2024
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Ablative fractional laser-assisted drug delivery has gained attention as a promising method for enhancing dermal drug absorption and improving therapeutic outcomes in dermatological conditions, particularly for hypertrophic and keloid scars. However, despite the growing number of clinical trials and case reports supporting its efficacy, there remains a scarcity of robust evidence on the topical bioavailability and dermato-pharmacokinetics of drugs in human subjects. This study aimed to examine the enhancement of triamcinolone acetonide (TAC) bioavailability following treatment with a fractional Erbium-Doped Yttrium Aluminum Garnet (Er: YAG) laser.
View Article and Find Full Text PDFJ Dent
December 2024
Faculty of Dentistry, The University of Hong Kong, Hong Kong, S.A.R., China. Electronic address:
Objective: To evaluate and compare the accuracy of detection methods for the diagnosis of secondary caries around direct restorations in posterior teeth.
Data: Accuracy parameters including sensitivity, specificity, diagnostic odds ratio (DOR), area under curve (AUC), and partial AUC (pAUC) are generated from studies assessing the accuracy of detection methods for secondary caries.
Sources: Publications from PubMed, Web of Science, Scopus, Medline, EMBASE and Cochrane Library databases.
Can J Ophthalmol
December 2024
Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.
Objective: To conduct a pilot study to evaluate and compare the 24-hour habitual intraocular pressure (IOP) and ocular perfusion pressure (OPP) fluctuation in glaucoma patients treated with medical therapy, selective laser trabeculoplasty (SLT) or trabeculectomy.
Design: Pilot study.
Participants: Criteria for inclusion were patients aged 18 years or older with well-controlled IOP with either maximum tolerated medical therapy, previous SLT, or previous trabeculectomy.
Adv Sci (Weinh)
December 2024
Department of Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, 999077, China.
Transition metal carbides, nitrides, and carbonitrides (MXenes) have emerged as a promising class of 2D materials that can be used for various applications. Recently, a new form of high-entropy MXenes has been reported, which contains an increased number of elemental species that can increase the configurational entropy and reduce the Gibbs free energy. The unique structure and composition lead to a range of intriguing and tunable characteristics.
View Article and Find Full Text PDFPLoS One
December 2024
Faculty of Health, Maastricht MultiModal Molecular Imaging Institute (M4I), Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Mass spectrometry imaging (MSI) is a well-established technique that allows to determine the distribution of small molecules, such as lipids, metabolites, and drugs, as well as large molecules in tissue sections. Because of the tissue heterogeneity, resulting in different matrix effects, and to the fact that the measured compounds are not entirely "extracted" from the tissue during the measurement, the absolute quantitative aspect of MSI is limited. To combine compound quantification with spatial information on fresh frozen unstained tissue sections, laser (capture) microdissection has been used to isolate tissue sections for compound extraction and LC-MS/MS quantification.
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