A transition metal carbonyl probe for use in a highly specific and sensitive SERS-based assay for glucose.

J Am Chem Soc

Singapore Bioimaging Consortium, Agency for Science, Technology and Research , Singapore.

Published: December 2013

A triosmium carbonyl cluster-boronic acid conjugate is used as a secondary carbohydrate probe in a SERS-based assay. The assay does not require conjugation of the metal carbonyl probe to a SERS-active species, and it utilizes the CO stretching vibrations of the metal carbonyl, which lies in a silent region of the SERS spectrum (1800-2200 cm(-1)), for quantification. High selectivity for glucose over fructose and galactose is obtained, and a human urine sample doped with glucose is detected accurately.

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Source
http://dx.doi.org/10.1021/ja409230gDOI Listing

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