Little is known on the role of distinct B-cell subtypes in human malignancies. We have recently performed a multiplex characterization of B cells in patient-derived tumor-associated tissues, documenting the activation and antigen-driven differentiation of B cells in metastatic lymph nodes and neoplastic lesions. Here we discuss the role of B lymphocytes as antigen-presenting cells and catalysts of T cell-based immunotherapies in view of these findings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805648 | PMC |
| http://dx.doi.org/10.4161/onci.25237 | DOI Listing |
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