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Impulse Control Disorders by Dopamine Partial Agonists: A Pharmacovigilance-Pharmacodynamic Assessment Through the FDA Adverse Event Reporting System.
Int J Neuropsychopharmacol
September 2022
Pharmacology Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Background: The dopaminergic partial agonism of the so-called third-generation antipsychotics (TGAs; aripiprazole, brexpiprazole, cariprazine) is hypothesized to cause impulse control disorders (ICDs). Relevant warnings by the Food and Drug Administration (FDA) were posted on aripiprazole (2016) and brexpiprazole (2018). Our study investigated the FDA Adverse Event Reporting System and the pharmacodynamic CHEMBL database to further characterize TGA-induced ICDs.
View Article and Find Full Text PDFCurrent Management of Tics and Tourette Syndrome: Behavioral, Pharmacologic, and Surgical Treatments.
Neurotherapeutics
October 2020
Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 7200 Cambridge, Suite 9A, Houston, TX, 77030-4202, USA.
Tourette syndrome is a heterogeneous neurobehavioral disorder manifested by childhood-onset motor and phonic tics, often accompanied by a variety of behavioral comorbidities, including attention deficit and obsessive compulsive disorder. Treatment must be tailored to the needs and goals of the individual patients and their families. All patients should receive education on the condition and, if possible, engage behavioral therapy targeted towards tics and/or comorbidities.
View Article and Find Full Text PDFZiprasidone in the treatment of bipolar disorder with comorbid obsessive-compulsive disorder and gambling disorder.
Bipolar Disord
June 2020
Department of Very Important Patient, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Toxic Myopathy due to Antidopaminergic Medication Without Neuroleptic Malignant Syndrome.
J Clin Neuromuscul Dis
December 2018
Departments of Pediatrics and.
Severe recurrent proximal muscle weakness without neuroleptic malignant syndrome secondary to antidopaminergic medication has rarely been reported. We report a 29-year-old man with history of obsessive compulsive disorder and Tourette syndrome who presented with 2 months of worsening dyspnea 3 weeks after starting ziprasidone 40 mg daily that required mechanical ventilation. A year before, after an increased risperidone dose from 0.
View Article and Find Full Text PDFThe colorful spectrum of Tourette syndrome and its medical, surgical and behavioral therapies.
Parkinsonism Relat Disord
January 2018
Dept. of Neurology and Center of Clinical Neuroscience, First Medical Faculty, Charles University and General Hospital in Prague, Kateřinská 30, 120 00, Czech Republic. Electronic address:
Tourette syndrome (TS) is a common neuropsychiatric disorder, more common in males than females, with onset before age 18. TS is characterized by multiple motor tics and one or more vocal/phonic tics, persisting for more than a year. Tics are unvoluntary, abrupt, rapid, repetitive, but non-rhythmic movements or sounds (vocalizations).
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