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| http://dx.doi.org/10.3389/fpsyg.2013.00723 | DOI Listing |
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Identification of atypical pediatric diabetes mellitus cases using electronic medical records.
BMJ Open Diabetes Res Care
November 2024
Texas Children's Hospital-Pediatric Diabetes & Endocrinology, Baylor College of Medicine Department of Pediatrics, Houston, Texas, USA.
Introduction: There are no established methods to identify children with atypical diabetes for further study. We aimed to develop strategies to systematically ascertain cases of atypical pediatric diabetes using electronic medical records (EMR).
Research Design And Methods: We tested two strategies in a large pediatric hospital in the USA.
Abdominal visceral-to-subcutaneous fat ratio in the prediction of metabolic syndrome risk in Japanese Americans followed prospectively for 10-years loses information.
Obes Res Clin Pract
September 2024
Seattle Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA; Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA.
Aims: Visceral fat predicts the development of metabolic syndrome (MetS), but it is not known whether the visceral to subcutaneous fat area ratio (VSR) measured using imaging predicts MetS risk as well or better. Thus, we aimed to examine if VSR predicted future risk of MetS over 10-years.
Methods: We followed 329 participants in the longitudinal Japanese American Community Diabetes Study without MetS at baseline for its development over 10 years.
Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial.
Lancet
August 2024
Department of Cardiovascular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Article Synopsis
- Semaglutide, a GLP-1 receptor agonist used for weight loss, may lower the risk of serious cardiovascular issues in individuals with obesity, but its specific effects on those with pre-existing heart conditions, like atherosclerotic cardiovascular disease and heart failure, were unclear.
- The SELECT trial, a comprehensive study involving adult participants with cardiovascular disease and high BMI, examined the impact of weekly injections of semaglutide versus placebo on heart-related outcomes, particularly focusing on those with varying types of heart failure.
- Researchers looked for differences in cardiovascular events, analyzing data to see if treatment efficacy and safety were affected by heart failure type and participants’ initial health characteristics.
Testing a Context-Enriched Model of Successful Aging in Multiple Large Data Infrastructures With Individuals in Advanced Old Age.
Gerontologist
December 2024
Network Aging Research, Heidelberg University, Heidelberg, Baden-Wuerttemberg, Germany.
Article Synopsis
- Many individuals aged 80 and older do not meet the traditional criteria for successful aging (SA) as defined by Rowe and Kahn, highlighting the need for a broader, context-focused understanding, especially for this age group.
- *A study utilizing two large surveys found that while only 9.1% of adults aged 80-84 and 0.7% of those 90+ met the classic SA criteria, a significantly higher percentage achieved SA when considering contextual factors (54.9% and 44.4%, respectively).
- *The research suggests that enhancing community contexts can greatly improve successful aging outcomes for older adults, indicating a shift in policy focus is necessary.*
Higher alpha diversity and Lactobacillus blooms are associated with better engraftment after fecal microbiota transplant in inflammatory bowel disease.
Sci Rep
August 2024
Gastroenterology/Nutrition, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, USA.
Fecal Microbiota Transplant (FMT) has shown some success in treating inflammatory bowel diseases (IBD). There is emerging evidence that host engraftment of donor taxa is a tenet of successful FMT. We undertook a double-blind, randomized, placebo-controlled pilot study to characterize the response to FMT in children and young adults with mild to moderate active Crohn's disease (CD) and ulcerative colitis (UC).
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