Histones are highly cationic proteins that are essential components of the cell nucleus, interacting with DNA to form the nucleosome and regulating transcription. Histones, however, can transit from the cell nucleus during cell death and, once in an extracellular location, can serve as danger signals and activate immune cells. An article in this issue of the European Journal of Immunology [Eur. J. Immunol. 2013. 43: 3336-3342] reports that histones can activate monocyte-derived DCs via the NRLP3 inflammasome to induce the production of IL-1β. As such, histones, which can also stimulate TLRs, may drive events in the immunopathogenesis of a wide range of acute and chronic diseases marked by sterile inflammation. While the mechanism of this stimulation is not known, the positive charge of histones may provide a structural element to promote interaction with cells and activation of downstream signaling systems.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/eji.201344175 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Several particular kinds of typical morphology characteristics of leukemic blasts associated with the specific subtypes of leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely been reported. The purpose of this study was to investigate the correlation of TCF3::PBX1 fusion with multiple clefts nuclei of blasts in patients with B-ALL/LBL.
View Article and Find Full Text PDFApplying first & second harmonic spectral phasor analysis on a single-wavelength calcium fluorophore.
Biochem Biophys Rep
March 2025
School of Science, Western Sydney University, Penrith, New South Wales, Australia.
Ratiometric and single-wavelength fluorophores are limited in their ability to provide basal level activity prior to treatment. This study presents a novel approach to characterise cell-wide basal activity of calcium using first and second harmonic spectral phasor analysis. Cells stained with the single-wavelength calcium fluorophore Oregon Green™ BAPTA 1-AM exhibited significant differences in wavelength or width in the nucleus, cytoplasm and membrane under basal conditions.
View Article and Find Full Text PDFCharacterization and genomic analysis of Sharanji: a jumbo bacteriophage of Escherichia coli.
Virol J
March 2025
Department of Biological Sciences, SRM University - AP, Amaravati, Andhra Pradesh, 522 240, India.
Background: Bacteriophages are the most genetically diverse biological entities in nature. Our current understanding of phage biology primarily stems from studies on a limited number of model bacteriophages. Jumbo phages, characterized by their exceptionally large genomes, are less frequently isolated and studied.
View Article and Find Full Text PDFChromosome-level genome assembly and annotation of pawak croaker (Pennahia pawak).
Sci Data
March 2025
National Engineering Research Center for Marine Facilities Aquaculture, Zhejiang Ocean University, Zhoushan, 316022, China.
The diversity of fish coloration is a fascinating scientific question. The pawak croaker (Pennahia pawak) is distinguished by its silver-white colour, setting it apart from other Sciaenidae species. However, the genomic information of this genus remains largely unexplored.
View Article and Find Full Text PDFA Chromosome-level genome assembly of the American bullfrog (Aquarana catesbeiana).
Sci Data
March 2025
College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, China.
The American bullfrog (Aquarana catesbeiana) is both an economically important aquaculture species and a globally distributed invasive organism with high environmental adaptability. In this study, we present a high-quality chromosome-level genome assembly for the species, comprising 13 chromosomes with a total length of 6.32 Gb and a scaffold N50 of 691.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!