AI Article Synopsis
- The study investigates the role of adipokines (resistin, leptin, adiponectin) in linking inflamed intestines and mesenteric fat in patients with active celiac disease (ACD) compared to those with diarrhea-predominant irritable bowel syndrome (IBS-d) and healthy individuals.
- It involves measuring the levels of these substances and specific genetic variations in patients to understand potential differences and effects from a gluten-free diet (GFD).
- Results show higher levels of resistin and adiponectin in ACD and IBS-d patients, indicating their involvement in inflammation, with GFD leading to significant changes in resistin levels but not in leptin or adiponectin.
Article Abstract
OBJECTIVE. The role of adipokines such as resistin, leptin, and adiponectin could be pivotal in the molecular crosstalk between the inflamed intestine and the surrounding mesenteric adipose tissue. Our aims were to a) evaluate their circulating concentrations in patients with active celiac disease (ACD) and compare them to those in patients with diarrhea-predominant irritable bowel syndrome (IBS-d) and healthy subjects; b) establish the impact of genetic variability in resistin; and c) evaluate whether a 1-year gluten-free diet (GFD) modifies circulating concentrations of resistin, leptin, and adiponectin in celiac patients. MATERIAL AND METHODS. The study included 34 ACD patients, 29 IBS-d patients, and 27 healthy controls. Circulating concentrations of resistin, leptin, adiponectin, IL-6, and IL-8 were evaluated at the time of enrollment. Resistin +299 G/A polymorphism was also analysed. In CD patients, biochemical measurements were repeated after a 1-year GFD. RESULTS. Along with higher IL-6 and IL-8 plasma levels, higher resistin and adiponectin concentrations were found in ACD and IBS-d patients compared with controls (p: 0.0351 and p: 0.0020, respectively). Resistin values proved to be predictable from a linear combination of IL-8 and +299 polymorphism. GFD affected resistin (p: 0.0009), but not leptin and adiponectin concentrations. CONCLUSIONS. Our data suggest that these adipokines are involved in modulating inflammatory processes in both CD and IBS-d patients. Alterations in the adipokine profile as well as the higher prevalence of the resistin +299 G/A SNP A allele compared to controls support the hypothesis that, at least in well-defined cases of IBS, a genetic component may also be supposed.
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| http://dx.doi.org/10.3109/00365521.2013.845907 | DOI Listing |
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