AI Article Synopsis
- Malaria is a major global health issue, affecting approximately 50% of the population and causing high morbidity and mortality, especially in developing countries, with Plasmodium falciparum being the primary parasite responsible.
- Drug resistance to existing antimalarials is a growing concern, making the search for new treatments critical, particularly those derived from plants.
- There are promising plant-based compounds that show better antimalarial activity than current drugs, highlighting the need for systematic evaluation to develop safe and cost-effective alternatives.
Article Abstract
Malaria is one of the deadliest diseases on the planet affecting about 50% of the population worldwide. It is a leading cause of morbidity and mortality in the developing world. Plasmodium falciparum, a tiny parasite is the major cause of malaria and is possibly the most dangerous stow-away in history. Malaria has become a major economic concern to some of the tropical and sub-tropical countries. Though a number of antimalarials have been developed from plants as such or their semi-synthetic analogues, there is again an alarming situation of drug resistance against most of the antimalarial drugs. Plants have been an excellent source of antimalarial compounds. There are several plant leads exhibiting antimalarial activity better than the existing drugs. A systematic evaluation of these plant based leads is the need of the time to develop safe, effective and affordable new antimalarials. The present review is an update of plant based antimalarial agents.
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| http://dx.doi.org/10.2174/09298673113206660291 | DOI Listing |
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