Voltage-gated sodium (Na) channels are required for impulse conductance in excitable tissues. Nas have been linked to human cancers, including prostate. The expression and distribution of Na isoforms (Na1.1-Na1.9) in human prostate cancer are not well established. Here, we evaluated the expression of these isoforms and investigated the expression of Na1.8 in human prostate cancer tissues. Na1.8 was highly expressed in all examined cells. Expression of Na1.1, Na1.2, and Na1.9 were high in DU-145, PC-3 and PC-3M cells compared to LNCaP (hormone-dependent), C4-2, C4-2B, and CWR22Rv-1 cells. Na1.5 and Na1.6 were expressed in all cells examined. Na1.7 expression was absent in PC-3M and CWR22Rv-1, but expressed in the other cells examined. Immunohistochemistry revealed intensive Na1.8 staining correlated with more advanced pathologic stage of disease. Increased intensity of nuclear Na1.8 correlated with increased Gleason grade. Our results revealed that Na1.8 is universally expressed in human prostate cancer cells. Na1.8 expression statistically correlated with pathologic stage (P=0.04) and Gleason score (P=0.01) of human prostate tissue specimens. The aberrant nuclear localization of Na1.8 with advanced prostate cancer tissues warrant further investigation into use of Na1.8 as a potential biomarker to differentiate between early and advanced disease.
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| http://dx.doi.org/10.4172/2324-9110.1000102 | DOI Listing |
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