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Clinical Manifestations.
Alzheimers Dement
December 2024
Imperial College London, Department of Brain Sciences, London, United Kingdom.
Background: Cognitive assessments are essential for detecting and monitoring cognitive changes in neurological populations. Compared to standard pen-and-paper tests, online cognitive tasks offer a more accessible, scalable, repeatable and cost-effective approach to assessment. Cognitron is an online cognitive assessment platform with previously demonstrated validity and reliability (1).
View Article and Find Full Text PDFPlatelets and monocytes: A dynamic duo aiding in the prediction of the clinical response to thrombopoietin receptor agonists in immune thrombocytopenia?
Br J Haematol
January 2025
Sanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Patients with immune thrombocytopenia (ITP) suffer from an autoimmune bleeding disorder with an isolated low number of platelets. Platelets and megakaryocytes are targeted by the immune system, due to a loss of immune tolerance, via the action of platelet-autoantibodies and/or cytotoxic T cells. ITP is a highly variable disorder regarding the underlying biological mechanisms, disease trajectories and treatment responses.
View Article and Find Full Text PDFThe tibiofibular mortise - anatomical controversies and their clinical importance: a historical and pictorial essay.
Int Orthop
January 2025
Institute of Anatomy, First Faculty of Medicine, Charles University, U Nemocnice 3, Prague 2, Prague, Czech Republic.
Introduction: During 280 years of studies of the anatomy of the distal tibiofibular articulation, there have arisen many unclear issues regarding the description of individual structures and their terminology. These historical inaccuracies were subsequently reflected in the clinical practice.
Materials And Methods: A literature search of original publications and historical sources was performed.
From Moral Distress to Moral Integrity: Qualitative Evaluation of a New Moral Conflict Assessment Tool.
Am J Crit Care
January 2025
Peter Dodek is a professor emeritus, Division of Critical Care Medicine and Center for Advancing Health Outcomes, St Paul's Hospital and University of British Columbia, Vancouver.
Background: Moral distress affects the well-being of health care professionals and can lead to burnout and attrition. Assessing moral distress and taking action based on this assessment are important. A new moral conflict assessment (MCA) designed to prompt action was developed and tested.
View Article and Find Full Text PDFClinical presentations and complications of lichen sclerosus: A systematic review.
J Dtsch Dermatol Ges
December 2024
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
Lichen sclerosus (LS) is a chronic, inflammatory dermatosis most commonly characterized by changes in skin pigmentation and pruritus, with associated dyspareunia and genital architectural changes. There are a variety of complications associated with LS, which further worsen a patient's health-related quality of life. A systematic review was conducted to summarize the literature regarding clinical features of LS, as well as LS-associated complications.
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