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Intersection of Race and Gender in the Cardiothoracic Workforce: Study of Representation and Salary.
Ann Thorac Surg
November 2024
Center for Asian Health, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania; Department of Thoracic Medicine and Surgery, Temple University Hospital, Philadelphia, Pennsylvania. Electronic address:
Background: Cardiothoracic surgery lacks gender and racial/ethnic diversity. Recent studies have highlighted disparities based on gender and race/ethnicity among academic cardiothoracic surgeons. The impact of the intersection of these factors on representation and salary is unknown.
View Article and Find Full Text PDFDataset on a reliability generalization meta-analysis of the Oxford COVID-19 vaccine hesitancy scale.
Data Brief
June 2024
ABU Distance Learning Center, Ahmadu Bello University Zaria, Nigeria.
The Oxford COVID-19 Vaccine Hesitancy Scale is a 7-item psychometric scale developed by Freeman and colleagues a year after detecting the first case of the disease in 2019. The scale assesses people's thoughts, feelings, and behavior toward COVID-19 vaccines. A comprehensive search of major electronic databases, including Scopus, Clarivate Analytics, and PubMed, was conducted to extract eligible articles for inclusion in this meta-analysis.
View Article and Find Full Text PDFAddressing Social Determinants in the Era of Precision Medicine in Breast Cancer: Is It Sufficient to Reduce Disparities?
Cancer Epidemiol Biomarkers Prev
May 2024
Department of Public Health Sciences, University of Chicago, Chicago, Illinois.
The Oncotype DX (ODX) assay predicts recurrence risk and demonstrates the benefits of adjuvant therapy in patients with early-stage, hormone receptor (HR)-positive/HER2-negative breast cancer. ODX uptake varies by patients' racial/ethnic backgrounds and socioeconomic status (SES). However, community-level variability remains unknown, and research regarding the association between testing status and receipt of adjuvant chemotherapy is limited.
View Article and Find Full Text PDFPD-1 Expression on Intratumoral Regulatory T Cells Is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear-Cell Renal Cell Carcinoma Patients.
Clin Cancer Res
February 2024
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
Purpose: Programmed cell death protein 1 (PD-1) expression on CD8+TIM-3-LAG-3- tumor-infiltrating cells predicts positive response to PD-1 blockade in metastatic clear-cell renal cell carcinoma (mccRCC). Because inhibition of PD-1 signaling in regulatory T cells (Treg) augments their immunosuppressive function, we hypothesized that PD-1 expression on tumor-infiltrating Tregs would predict resistance to PD-1 inhibitors.
Experimental Design: PD-1+ Tregs were phenotyped using multiparametric immunofluorescence in ccRCC tissues from the CheckMate-025 trial (nivolumab: n = 91; everolimus: n = 90).
A dive into the unknome.
Trends Genet
January 2024
Technische Universität Berlin, Chair of Bioanalytics, 10623 Berlin, Germany; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK; Si-M/'Der Simulierte Mensch', a Science Framework of Technische Universität Berlin and Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:
We may never understand the function of all genes, findings by Freeman, Munro and colleagues suggest, unless we rethink our approaches. They make a thorough attempt at quantifying the unknownness of protein-coding genes and experimentally prove that many neglected genes hold the seed of important discoveries.
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