AI Article Synopsis
- The study aimed to analyze the budget impact of switching from cyclosporine (CsA) to sirolimus (SRL) for renal transplant therapy from the perspective of insurance companies in Iran.
- An Excel model was used to compare costs, including immunosuppressants and related adverse events, finding that treating approximately 2,200 renal transplant patients would cost $4.85 million with CsA but only $4.3 million with SRL, representing a savings of $550,000 for insurers.
- The financial benefits of using SRL stemmed from reduced adverse event costs and lower doses of mycophenolate mofetil (MMF) needed, making it a more economical option for insurance organizations.
Article Abstract
Objectives: The aim of this study was to determine budget impact of conversion from cyclosporine (CsA) to sirolimus (SRL) in renal transplant therapy (RTT) from the perspective of insurance organizations in Iran.
Methods: An Excel-based model was developed to determine cost of RTT, comparing current CsA based therapy to an mTOR inhibitor-based therapy regimen. Total cost included both cost of immunosuppressive agents and relative adverse events. The inputs were derived from database of Ministry of Health and insurance organizations, hospital and pharmacy based registries, and available literature that were varied through a one-way sensitivity analysis. According to the model, there were almost 17,000 patients receiving RTT in Iran, out of which about 2,200 patients underwent the operation within the study year. The model was constructed based on the results of a local RCT, in which test and control groups received CsA, SRL, and steroids over the first 3 months posttransplantation and, from the fourth month on, CsA, mycophenolate mofetil (MMF), and steroids were used in the CsA group and SRL, MMF, and steroids were administered in the SRL group, respectively.
Results: The estimated cost of RTT with CsA was US$4,850,000 versus US$4,300,000 receiving SRL. These costs corresponded to the cost saving of almost US$550,000 for the payers.
Conclusion: To evaluate the financial consequence of adding mTOR inhibitors to the insurers' formulary, in the present study, a budget impact analysis was conducted on sirolimus. Fewer cases of costly adverse events along with lower required doses of MMF related to SRL based therapies were major reasons for this saving budgetary impact.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806112 | PMC |
| http://dx.doi.org/10.2147/CEOR.S51446 | DOI Listing |
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