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Severe Posaconazole-Induced Glucocorticoid Deficiency with Concurrent Pseudohyperaldosteronism: An Unfortunate Two-for-One Special.
J Fungi (Basel)
July 2021
Division of Hospital Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
A 56-year-old Hispanic man with a history of disseminated coccidioidomycosis was diagnosed with persistent glucocorticoid insufficiency and pseudohyperaldosteronism secondary to posaconazole toxicity. This case was notable for unexpected laboratory findings of both pseudohyperaldosteronism and severe glucocorticoid deficiency due to posaconazole's mechanism of action on the adrenal steroid synthesis pathway. Transitioning to fluconazole and starting hydrocortisone resolved the hypokalemia but not his glucocorticoid deficiency.
View Article and Find Full Text PDFEndocrine Hypertension: A Practical Approach.
Adv Exp Med Biol
October 2017
Department of Endocrinology & Diabetes, New Cross Hospital, The Royal Wolverhampton Hospital NHS Trust, Wolverhampton, WV10 0QP, UK.
Elevated blood pressure resulting from few endocrine disorders (endocrine hypertension) accounts for a high proportion of cases of secondary hypertension. Although some features may be suggestive, many cases of endocrine hypertension remain silent until worked up for the disease. A majority of cases result from primary aldosteronism.
View Article and Find Full Text PDFPseudohyperaldosteronism due to application of an antihemorrhoid cream.
Nephron
August 1989
Department of Endocrinology, Clinica Puerta de Hierro, Universidad Autónoma, Madrid, Spain.
Three cases of pseudohyperaldosteronism produced by the application of an antihemorrhoid cream containing 9 alpha-fluoroprednisolone are reported. All three presented edema, hypokalemia and metabolic alkalosis. Two of the patients also exhibited slight arterial hypertension.
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