Derivatives of aryl(heteroaryl)acetic acids or aryl(heteroaryl)methanes are formed from imidazole or thiazole N-oxide, 1,1-difluorostyrene, and an alcohol, amine, or water in a three-component reaction, which probably occurs via 1,3-dipolar cycloaddition. The whole process is a novel method for functionalization of a heterocyclic ring in a position originally occupied by hydrogen. Preliminary experiments show that it occurs for 6-membered N-oxides as well.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol402735m | DOI Listing |
Publication Analysis
Top Keywords
synthesis alkyl
4
alkyl arylheteroarylacetates
4
arylheteroarylacetates n-oxides
4
n-oxides 11-difluorostyrenes
4
11-difluorostyrenes alcohols
4
alcohols derivatives
4
derivatives arylheteroarylacetic
4
arylheteroarylacetic acids
4
acids arylheteroarylmethanes
4
arylheteroarylmethanes formed
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!