AI Article Synopsis
- Scientists study mice with poor blood flow in their back legs to explore ways to help grow new blood vessels for people with serious leg problems.
- They are especially interested in using special cells called mesenchymal stem cells (MSCs) that can help with this process.
- It's important to choose the right kind of mouse and stem cells because some mice heal faster and certain stem cells make more helpful growth factors.
Article Abstract
Murine models of hind-limb ischemia are frequently used to assess interventions aimed at improving therapeutic angiogenesis in critical limb ischemia. Much of the current focus of angiogenesis lies with mesenchymal stem cells (MSCs). Important considerations when using these models include the strain of mouse, because some strains recover from ischemia more rapidly than others, and the MSC source. MSCs derived from certain strains generate increased levels of growth factors such as vascular endothelial growth factor. This may significantly affect the limb?s ability to generate collateral vessels.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854850 | PMC |
| http://dx.doi.org/10.1186/scrt342 | DOI Listing |
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