Comparative review of interferometric detection of plasmonic nanoparticles.

Biomed Opt Express

Department of Biomedical Engineering and Fitzpatrick Institute for Photonics, Duke University, Durham NC 27708, USA.

Published: October 2013

AI Article Synopsis

  • Noble metal nanoparticles have enhanced light scattering and absorption at certain wavelengths because of localized surface plasmon resonance, making them useful as contrast agents in optical imaging.
  • Various optical techniques have been developed to detect these nanoparticles, and this review focuses on optical interferometry methods for measuring their presence and concentration.
  • The paper analyzes the strengths and weaknesses of different interferometry approaches, provides quantitative comparisons of signal-to-noise ratios, and outlines the advantages of each method for specific applications.

Article Abstract

Noble metal nanoparticles exhibit enhanced scattering and absorption at specific wavelengths due to a localized surface plamson resonance. This unique property can be exploited to enable the use of plasmonic nanoparticles as contrast agents in optical imaging. A range of optical techniques have been developed to detect nanoparticles in order to implement imaging schemes. Here we review several different approaches for using optical interferometry to detect the presence and concentration of nanoparticles. The strengths and weaknesses of the various approaches are discussed and quantitative comparisons of the achievable signal to noise ratios are presented. The benefits of each approach are outlined as they relate to specific application goals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799674PMC
http://dx.doi.org/10.1364/BOE.4.002166DOI Listing

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