Synthesis of the -labelled analogues of the carcinogenic polycyclic aromatic hydrocarbon benzo[]pyrene and its active metabolites are described. The method entails Pd-catalyzed Suzuki-Miyaura coupling of a naphthalene boronic acid with 2-bromobenzene-1,3-dialdehyde followed by Wittig reaction of the product with CH=PPh.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804341 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2008.05.033 | DOI Listing |
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