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HTLV infection in urban population from Mato Grosso do Sul, Central Brazil.
Retrovirology
November 2024
Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Background: Brazil has the highest number of HTLV-1 infection in Latin America, with around one million cases spread unevenly across regions. However, there is a limited number of studies on this infection in the general population. This cross-sectional study aimed to estimate the prevalence of HTLV as well as identify types, and subtypes of HTLV among the urban population of Campo Grande, capital of Mato Grosso do Sul state (MS).
View Article and Find Full Text PDFThe Global Prevalence of HTLV-1 and HTLV-2 Infections among Immigrants and Refugees-A Systematic Review and Meta-Analysis.
Viruses
September 2024
Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia 74605-050, Goiás, Brazil.
This is the first systematic review and meta-analysis to estimate the prevalence of human T-lymphotropic virus 1 and 2 (HTLV-1 and 2) infections among immigrants and refugees worldwide. PubMed/MEDLINE, Scopus, EMBASE, Web of Science, and Virtual Health Library (VHL) databases were searched for studies published from their inception to 6 January 2023. A meta-analysis using a generalized linear mixed model with a random effect was performed for HTLV-1 and HTLV-2.
View Article and Find Full Text PDFIntrafamilial Transmission of HTLV-1 and HTLV-2 in Indigenous Peoples of the Brazilian Amazon: Molecular Characterization and Phylogenetic Analysis.
Viruses
September 2024
Laboratório de Virologia, Universidade Federal do Pará, Belém 66075-110, Brazil.
Human T-limphotropic virus 1 infection has a global distribution, with a high prevalence in some regions of Brazil and the world, while HTLV-2 infection is endemic mainly among indigenous people and drug users. To analyze intrafamilial transmission of HTLV-1/2 in five Kayapó indigenous peoples (Gorotire, Kararaô, Kokraimoro, Kubenkokre, and Xikrin do Bacajá), we investigated 1452 individuals who underwent serological and molecular tests. Among the 276 indigenous people with positive results, we identified intrafamily transmission in 42.
View Article and Find Full Text PDFA Systematical Review on ART Use in HTLV Infection: Clinical, Virological, and Immunological Outcomes.
Pathogens
August 2024
Laboratório de Pesquisa em Infectologia (LAPI), Hospital Universitário Professor Edgard Santos, Federal University of Bahia, Salvador 40110-060, Brazil.
Human T-cell lymphotropic virus (HTLV) infection affects over ten million people worldwide, but there is no effective treatment so far. This review describes the virological, immunological, and clinical outcomes of antiretroviral therapy (ART) in people with HTLV infection. This systematic review followed PRISMA reporting guidelines and was registered in PROSPERO: CRD42022350076.
View Article and Find Full Text PDFLow-cost and simple PCR process for access to molecular diagnosis of HTLV-1/2 in low-resource countries.
Acta Trop
December 2024
Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Centro de Referencia en Identificación Genética Humana (CRIGH), Servicio de Huellas Digitales Genéticas (SHDG) y Cátedra de Genética Forense, Universidad de Buenos Aires, Buenos Aires, Argentina. CONICET, Buenos Aires, Argentina. Electronic address:
Background: HTLV-1/2 exhibit a widespread distribution globally and are associated with severe clinical manifestations, necessitating precise viral identification for diagnosis. Currently, there are no official diagnostic guidelines, and a variety of published protocols exists. We introduce an enhanced nested real-time PCR technique followed by high-resolution melting (rtPCR-HRM), designed to offer a cost-effective and straightforward tool for the simultaneous identification of both viruses.
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