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Utility of a commercial PCR assay and a clinical prediction rule for detection of toxigenic Clostridium difficile in asymptomatic carriers. | LitMetric
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Utility of a commercial PCR assay and a clinical prediction rule for detection of toxigenic Clostridium difficile in asymptomatic carriers.

Curtis J Donskey Venkata C K Sunkesula Annette L Jencson Nimalie D Stone Carolyn V Gould L Clifford McDonald Matthew Samore Jeanmarie Mayer Susan Pacheco Susan Sambol Laurica Petrella Deborah Terry Dale N Gerding

J Clin Microbiol

Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.

Published: January 2014

A commercial PCR assay of perirectal swab specimens detected 17 (68%) of 25 asymptomatic carriers of toxigenic Clostridium difficile, including 93% with skin and/or environmental contamination. A clinical prediction rule, followed by PCR screening, could be used to identify carriers at high risk of C. difficile shedding.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911416PMC
http://dx.doi.org/10.1128/JCM.01852-13DOI Listing

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