AI Article Synopsis
- Infertility linked to metabolic syndrome has a global prevalence of 10%-20%, as noted by the World Health Organization.
- Evidence suggests that the renin-angiotensin system plays a significant role in fertility issues across populations.
- Alterations in angiotensin-converting enzymes may contribute to infertility in both genders, but further research is necessary to determine the impact of the angiotensin-converting enzyme-3 pseudogene on human reproduction.
Article Abstract
According to the World Health Organization, infertility, associated with metabolic syndrome, has become a global issue with a 10%-20% incidence worldwide. An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in some populations. Moreover, alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting enzyme-3 might be one of the most important mechanisms underlying both female and male infertility. However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 gene could result in the problems of human reproduction. In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure for the treatment of infertility is discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3821659 | PMC |
| http://dx.doi.org/10.3390/ijms141021071 | DOI Listing |
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