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Stabilized Wittig olefination for bioconjugation. | LitMetric
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Stabilized Wittig olefination for bioconjugation.

Kenneth M Lum Vanessa J Xavier Michelle J-H Ong Charles W Johannes Kok-Ping Chan

Chem Commun (Camb)

Division of Organic Chemistry, Institute of Chemical and Engineering Sciences, Agency for Science Technology and Research Singapore, 11 Biopolis Way, Helios Block #03-08, Singapore.

Published: December 2013

Stabilized Wittig olefination holds great potential as a bioconjugation reaction. We demonstrate that the reaction of stabilized phosphorus ylides (or phosphonium salts) with aryl aldehydes is sufficiently robust to be used for live cell affinity isolation and fluorescence tagging of a protein, FKBP12.

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 Source
http://dx.doi.org/10.1039/c3cc45961fDOI Listing

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