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HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia.
J Clin Invest
January 2025
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, United States of America.
Although nucleoporin 98 (NUP98) fusion oncogenes often drive aggressive pediatric leukemia by altering chromatin structure and expression of HOX genes, underlying mechanisms remain elusive. Here, we report that a Hoxb-associated lncRNA HoxBlinc was aberrantly activated in NUP98-PHF23 fusion-driven leukemias. HoxBlinc chromatin occupancies led to elevated MLL1 recruitment and aberrant homeotic topologically associated domains (TADs) that enhanced chromatin accessibilities and activated homeotic/hematopoietic oncogenes.
View Article and Find Full Text PDFGlia control experience-dependent plasticity in an olfactory critical period.
Elife
January 2025
Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, United States.
Sensory experience during developmental critical periods has lifelong consequences for circuit function and behavior, but the molecular and cellular mechanisms through which experience causes these changes are not well understood. The antennal lobe houses synapses between olfactory sensory neurons (OSNs) and downstream projection neurons (PNs) in stereotyped glomeruli. Many glomeruli exhibit structural plasticity in response to early-life odor exposure, indicating a general sensitivity of the fly olfactory circuitry to early sensory experience.
View Article and Find Full Text PDFA positive empathy intervention to improve well-being on Instagram.
Emotion
January 2025
Department of Psychology, University of Toronto, Scarborough.
With more than half the global population on social media, there is a critical need to understand how to engage it in a way that improves rather than worsens user well-being. Here, we show that positive empathy is a promising tool. Participants who received brief positive empathy instructions before 10 min of browsing their own Instagram feed showed greater affective well-being (Studies 1-4) and life satisfaction (Study 4) at posttest relative to participants who were instructed to browse as usual.
View Article and Find Full Text PDFThe involuntary experience of digital exclusion among older adults: A taxonomy and theoretical framework.
Am Psychol
January 2025
Department of Management, Warrington College of Business, University of Florida.
The emerging phenomenon of digital exclusion raises an important issue that not everyone is equally engaged in and can benefit from the digital world. Older adults are particularly susceptible to digital exclusion, but a comprehensive conceptual treatment of digital exclusion in older adults is lacking in the psychology literature. In this article, we provide a taxonomy to advance the literature on digital exclusion in older adults, identifying key conceptual attributes of older adults' digital exclusion experiences by articulating both structural (i.
View Article and Find Full Text PDFThe prevalence of autoimmune thyroiditis is not increased in women with polycystic ovary syndrome after adjustment for family predisposition.
Endocrine
January 2025
Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Purpose: Several studies suggest a linkage between PCOS and autoimmunity with a high frequency of chronic autoimmune thyroiditis (AIT) reported in PCOS patients, however, this subject remains controversial. The aim of this study was to investigate the prevalence of AIT in PCOS women and identify parameters that would serve as independent predictors of AIT.
Methods: Two hundred fifty seven (257) PCOS patients according to the NIH criteria and one hundred forty three (143) controls, women with normal menstrual cycles and without clinical or biochemical hyperandrogenism, were recruited for the study.
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