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"We Work in an Industry Where We're Here to Care for Others, and Often Forget to Take Care of Ourselves": Aged-Care Staff Views on Self-Care.
Geriatrics (Basel)
January 2025
Research Centre for Palliative Care, Death and Dying, Palliative and Supportive Services, College of Nursing and Health Sciences, Flinders University, Adelaide, SA 5042, Australia.
: This study aimed to explore self-care understanding and behaviours among aged-care workers in Australia. It was conducted as part of a project to co-produce a self-care resource for the Australian aged-care workforce. : Semi-structured interviews with eleven aged-care staff and a focus group with four staff at an aged-care facility were undertaken to understand how staff understand and practice self-care and how death and dying affect workers.
View Article and Find Full Text PDFuORF-targeting steric block antisense oligonucleotides do not reproducibly increase RNASEH1 expression.
Mol Ther Nucleic Acids
March 2025
Department of Paediatrics, University of Oxford, Headington, Oxford OX3 7TY, UK.
Upstream open reading frames (uORFs) are -regulatory motifs that are predicted to occur in the 5' UTRs of the majority of human protein-coding transcripts and are typically associated with translational repression of the downstream primary open reading frame (pORF). Interference with uORF activity provides a potential mechanism for targeted upregulation of the expression of specific transcripts. It was previously reported that steric block antisense oligonucleotides (ASOs) can bind to and mask uORF start codons to inhibit translation initiation, and thereby disrupt uORF-mediated gene regulation.
View Article and Find Full Text PDFSchizophrenia and antipsychotic medications present distinct and shared gut microbial composition: A meta-analysis.
Schizophr Res
December 2024
Neuro-psychiatric Institute, Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264, Guangzhou Road, Nanjing, China. Electronic address:
There are some conflicting results regarding alterations of gut microbial composition in schizophrenia (SZ), even a few meta-analysis studies have addressed this field. Ignoring of antipsychotic medication effects may cause the large heterogeneity and impact on study results. This study is a meta-analysis to systematically evaluate composition of gut microbiota in patients with SZ, to elucidate the impact of antipsychotic use and reveal distinct and shared gut bacteria in SZ and antipsychotic medications.
View Article and Find Full Text PDFWe're All Healthier Under a Starry Sky.
AMA J Ethics
October 2024
Cardiologist from Salem, Massachusetts.
A star-filled sky has long been a source of awe and inspiration, and its loss adversely affects human, nonhuman, and environmental health. In one generation, this majestic nighttime overstory has been lost due to national and international overuse of light-emitting diodes lighting. This article canvasses ill health effects of excessive light at night.
View Article and Find Full Text PDFCapturing non-Markovian polaron dressing with the master equation formalism.
J Chem Phys
October 2024
Department of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Understanding the dynamics of open quantum systems in strong coupling and non-Markovian regimes remains a formidable theoretical challenge. One popular and well-established method of approximation in these circumstances is provided by the polaron master equation (PME). In this work, we re-evaluate and extend the validity of the PME to capture the impact of non-Markovian polaron dressing, induced by non-equilibrium open system dynamics.
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