Background: This study aimed to identify predictors of hearing thresholds (best-ear pure-tone average at 1, 2, and 4 kHz) and hearing deterioration in order to define potential target groups for hearing screening.
Methods: We analyzed data from the Maastricht Aging Study, a Dutch cohort (aged 24-81 years; N = 1,721) that was observed for 12 years. Mixed model analysis was used to calculate each participant's average hearing threshold deterioration rate during the follow-up period. We built ordinary least square linear regression models to predict the baseline threshold and deterioration rate. Potential predictors included in these models were age, gender, type of occupation, educational level, cardiovascular disease, diabetes, systemic inflammatory disease, hypertension, obesity, waist circumference, smoking, and physical activity level. We also examined the relationship between baseline threshold and the deterioration rate.
Results: Poorer baseline thresholds were strongly associated with faster hearing deterioration. Higher age, male gender, manual occupation, and large waist circumference were statistically significantly associated with poorer baseline thresholds and faster deterioration, although the effects of occupation type and waist circumference were small.
Conclusions: This study indicates that age and gender must be taken into account when determining the target population for adult hearing screening and that the time interval between repeated screenings should be based either on age or on the hearing thresholds at the first screening.
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http://dx.doi.org/10.1093/gerona/glt172 | DOI Listing |
Am J Otolaryngol
December 2024
Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing Institute of Otolaryngology, Beijing, China; Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing, China. Electronic address:
Purpose: To explore how hearing changes over time and the characteristics associated with progressive hearing loss in children with enlarged vestibular aqueduct (EVA), and develop a prediction model for anticipation of hearing progression probability.
Methods: A retrospective analysis was conducted on 48 children (92 ears) diagnosed with EVA. A total of 314 audiograms were included in the analysis of hearing loss trajectories using linear mixed-effects model.
Hear Res
December 2024
School of Mathematical and Statistical Sciences, The University of Texas Rio Grande Valley, Edinburg, TX, 78539, USA.
Hearing loss, particularly age-related hearing loss, significantly impacts health and quality of life worldwide. While much of the research has focused on older adults, the early stages of hearing decline remain relatively unexplored. Longitudinal studies examining hearing changes across the adult lifespan, especially at extended high frequencies (EHFs), are scarce.
View Article and Find Full Text PDFEJHaem
December 2024
Department of Clinical Outcome Analytics Evidera PPD Waltham Massachusetts USA.
Introduction: The study aimed to establish meaningful thresholds at patient and group levels for the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire CLL-specific module (EORTC QLQ-CLL17) domain scores in adults with relapsed or refractory (R/R) chronic lymphocytic leukaemia (CLL).
Material And Methods: Data for the analysis were from the TRANSCEND CLL 004 study (NCT03331198). EORTC QLQ-CLL17 and selected anchor measures were assessed at baseline and multiple postbaseline visits up to 24 months after treatment initiation.
Materials (Basel)
December 2024
English Heritage, Ranger's House, Chesterfield Walk, London SE10 8QX, UK.
This study examines the preservation challenges of archaeological iron, bone, and glass within shared environments focusing on material-specific degradation mechanisms. The relative humidity (RH) requirements for these materials can vary significantly. Iron presents distinct stability groups at specific RH thresholds, albeit levels below 30% RH are recommended for sensitive artefacts.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Cardiac implantable electronic devices (CIEDs) such as pacemakers and implantable cardioverter-defibrillators (ICDs) are increasingly used in the aging population. Modern CIEDs perform daily measurements, mainly aimed at discovering early signs of battery depletion or electrode dysfunction. Changes in thresholds, intracardiac signals, and pacing impedances can be caused by exacerbation of existing conditions or novel clinical problems.
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