The expression of HLA class I alpha chains by clones derived from a human X mouse T-cell line containing human chromosomes 6 and 15 was analysed by immunofluorescence. Evidence is presented showing that the expression of HLA class I alpha chains is associated with HLA-beta 2m. This is based on the phenotypic and quantitative fluorescence flow cytometric analysis of a series of cloned hybrids. In contrast, HLA and H-2 class I determinants show no evidence of such correlation. Results of cell-sorting indicate that the loss of HLA class I alpha chain expression is due to phenotypic modulation, in addition to gene segregation.
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| http://dx.doi.org/10.1111/j.1399-0039.1985.tb00944.x | DOI Listing |
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