Two new phenylpropanoid glycosides, 1,3,4-tri-O-(E)-caffeoyl-β-d-glucopyranoside (1) and 1,4-di-O-(E)-caffeoyl-β-d-glucopyranoside (2), along with four known phenylpropanoid glycosides (3-6), were isolated from the roots of Aruncus sylvester. The structures of 1 and 2 were elucidated using various spectroscopic methods. Compounds 1 and 2 displayed significant scavenging activity of 2,2-diphenyl-1-picrylhydrazyl free radicals with IC50 values of 110 and 258 μM (ascorbic acid: IC50 = 574 μM).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10286020.2013.841676 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of Bioactive Compounds from the Roots of and Their In Silico and In Vitro AMPK Activation Potential.
Molecules
December 2024
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Libosch., which belongs to the Orobanchaceae family, is a perennial herb found in China, Japan, and Korea. In traditional medicine, it is used to cool the body, improve water metabolism in the kidney, and provide protection from metabolic diseases such as type 2 diabetes mellitus (T2DM) and obesity.
View Article and Find Full Text PDFBis-Iridoid Glycosides and Triterpenoids from and Their Potential as Inhibitors of ACC1 and ACL.
Molecules
December 2024
Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, School of Pharmaceutical Sciences, Taizhou University, Taizhou 318000, China.
A comprehensive phytochemical investigation of the twigs/leaves and flower buds of , a rare deciduous shrub native to China, led to the isolation of 39 structurally diverse compounds. These compounds include 11 iridoid glycosides (- and -), 20 triterpenoids (, , and -), and 8 phenylpropanoids (-). Among these, amabiliosides A () and B () represent previously undescribed bis-iridoid glycosides, while amabiliosides C () and D () feature a unique bis-iridoid-monoterpenoid indole alkaloid scaffold with a tetrahydro--carboline-5-carboxylic acid moiety.
View Article and Find Full Text PDFNovel inhibition of sortase A by plantamajoside: implications for controlling multidrug-resistant infections.
Appl Environ Microbiol
December 2024
Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Article Synopsis
- The research introduces plantamajoside (PMS) as an innovative inhibitor of sortase A (SrtA), an enzyme crucial for the virulence of methicillin-resistant Staphylococcus aureus (MRSA), showcasing its potential in combating multi-drug resistant pathogens.
- PMS effectively reduces MRSA's ability to adhere to surfaces and form biofilms, leading to increased survival rates in infected cell models and proving beneficial in animal models by lowering mortality rates and bacterial loads.
- The findings emphasize the significance of targeting specific bacterial mechanisms, such as SrtA, to develop new therapeutic strategies against antibiotic-resistant infections, particularly MRSA.
Three new compounds of Umbelopsis dimorpha VDG10, a dominant endophytic fungus from Vaccinium dunalianum Wight.
Fitoterapia
December 2024
Key Laboratory of State Forestry and Grassland Administration on Highly-Efficient Utilization of Forestry Biomass Resources in Southwest China, Southwest Forestry University, Kunming 650233, PR China. Electronic address:
Three novel compounds, including an aromatic amino acid, dimorine A (1), a suncheonoside derivative, dimoroside A (2), and a phenylpropanoid glycoside, dimoroside B (3), together with four known compounds (4-7) were separated from Umbelopsis dimorpha VDG10, the predominant endophytic fungus found in the roots of Vaccinium dunalianum Wight (Ericaceae). Their structures were elucidated by spectroscopic methods, and the ECD spectrum confirmed the absolute configuration of 3. In addition, the antifungal activities of novel compounds against five phytopathogenic fungi were evaluated.
View Article and Find Full Text PDFPlant-derived natural compounds for the treatment of acute lung injury: A systematic review of their anti-inflammatory effects in animal models.
Int Immunopharmacol
December 2024
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China; Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing 100700, China. Electronic address:
Backgrounds And Aims: Acute lung injury (ALI) is a complex pulmonary disease characterized by a severe inflammatory response. The management of ALI presents a formidable challenge due to the intricate nature of its inflammatory cascade. Numerous studies have highlighted the potential therapeutic benefits of plant-derived natural compounds (PNCs) in treating inflammatory diseases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!