AI Article Synopsis
- Targeted cargo delivery systems can effectively address the challenges of delivering antileishmanials by overcoming physiological barriers, despite some existing market limitations.
- This review discusses the biology of leishmaniasis, how particulate systems interact with biological environments, and various targeting strategies including current therapies and the role of polymeric nanotechnology.
- There is a pressing need for the development of site-specific antileishmanial carriers to enhance treatment effectiveness, reduce toxicity, and combat drug-resistant strains, with polymeric systems showing great promise in improving drug delivery outcomes and commercial viability.
Article Abstract
Introduction: Targeted cargo delivery systems can overcome drawbacks associated with antileishmanials delivery, by defeating challenges of physiological barriers. Various colloidal particulate systems have been developed in the past; few of them even achieved success in the market, but still are limited in some ways.
Areas Covered: This review is focused on the pathobiology of leishmaniasis, interactions of particulate systems with biological environment, targeting strategies along with current conventional and vaccine therapies with special emphasis on polymeric nanotechnology for effective antileishmanial cargo delivery.
Expert Opinion: The problems concerned with limited accessibility of chemotherapeutic cargos in conventional modes to Leishmania-harboring macrophages, their toxicity, and resistant parasitic strain development can be sorted out through target-specific delivery of cargos. Vaccination is another therapeutic approach employing antigen alone or adjuvant combinations delivered by means of a carrier, and can provide preventive measures against human leishmaniasis (HL). Therefore, there is an urgent need of designing site-specific antileishmanial cargo carriers for safe and effective management of HL. Among various colloidal carriers, polymeric particulate systems hold tremendous potential as an effective delivery tool by providing control over spatial and temporal distribution of cargos after systemic or localized administration along with enhancing their stability profile at a comparatively cost-effective price leading to improved chances of commercial applicability.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1517/17425247.2013.838216 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Real-time monitoring of small changes in powder blends and ejected tablets in a low-dose formulation with 1 %w/w of active pharmaceutical ingredient using Raman and near-infrared spatially resolved spectroscopy within a tablet press.
Int J Pharm
January 2025
Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, 08854, USA; Center for Structured Organic Particulate Systems (C-SOPS), Cranbury, NJ, 08512, USA.
This study used Raman and near-infrared (NIR) spectroscopy to monitor small real-time changes in powder blends and tablets in low-dose pharmaceutical formulations. The research aims to enhance process analytical technology (PAT) in pharmaceutical manufacturing, ensuring high-quality and uniform products with applications to produce drugs with narrow therapeutic indices (NTI). The study utilizes Raman and NIR spatially resolved spectroscopy (SRS) techniques to monitor a moderate cohesive material's active pharmaceutical ingredient (API) concentrations during manufacturing.
View Article and Find Full Text PDFThe combined effects of microplastics and their additives on mangrove system: From the sinks to the sources of carbon.
Sci Total Environ
January 2025
College of Environmental Science and Engineering, Tongji University, State Key Laboratory of Pollution Control and Resource Reuse, Ministry of Education Key Laboratory of Yangtze River Water Environment, Shanghai 200092, China; Frontiers Science Center for Intelligent Autonomous Systems, Shanghai 200092, China; Institute of Carbon Neutrality, Tongji University, Shanghai 200092, China. Electronic address:
Mangrove ecosystems, a type of blue carbon ecosystems (BCEs), are vital to the global carbon cycle. However, the combined effects of microplastics (MPs) and plastic additives on carbon sequestration (CS) in mangroves remain unclear. Here, we comprehensively review the sources, occurrence, and environmental behaviors of MPs and representative plastic additives in mangrove ecosystems, including flame retardants, such as polybrominated diphenyl ethers (PBDEs), and plasticizers, such as phthalate esters (PAEs).
View Article and Find Full Text PDFExposure of Young Mice to Atmospherically Relevant PM Has Sex-Dependent Long-Lasting Impacts on the Skeletal Muscle System.
Aging Dis
December 2024
Department of Sports Science, College of Natural Science, Jeonbuk National University, Jeonju 54896, Korea.
The negative effects of particulate matter up to 2.5 μm in diameter (PM) and their mediating mechanisms have been studied in various tissues. However, little is known about the mechanism and long-term tracking underlying the sex-dependent effects of PM on skeletal muscle system modulation.
View Article and Find Full Text PDFThermogelation of nanoemulsions stabilized by a commercial pea protein isolate: high-pressure homogenization defines gel strength.
Soft Matter
January 2025
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
The impact of animal-based food production on climate change drives the development of plant-based alternatives. We demonstrate the use of colloidal thermogelation on a real nanoemulsion system to create structured gels that could be of interest for thermo-mechanical processing of next-generation plant-based food applications. We use a commercial pea protein isolate (PPI) without further purification to stabilize a 20 vol% peanut oil-in-water nanoemulsion at pH = 7 by high-pressure homogenization (HPH) and demonstrate the temperature induced gelation behavior of the nanoemulsion as a function of the HPH processing parameters.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Ecole polytechnique - CNRS UMR7654, Palaiseau, Ile-de-France, France; Université Paris Cité - Inserm UMR-S1124, Paris, Ile-de-France, France.
Alzheimer's disease (AD) is the most common dementia in humans that today concerns 50 million individuals worldwide and will affect more than 100 million people in 2050. Except for familial AD cases (<5% of AD patients) for which AD pathology connects to mutations in critical genes involved in the processing of the amyloid precursor protein into neurotoxic Aß peptides, it remains unknown what provokes the overproduction and deposition of Aß peptides in the brain of sporadic AD cases (>95% of AD patients). Some nanosized materials, e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!