AI Article Synopsis
- Cordyceps sinensis is a traditional Chinese herb commonly used for respiratory issues, but its effectiveness lacks solid experimental support.
- Research using NOD mice, which model type I diabetes, showed that C. sinensis extract can slow the progression of the disease.
- The extract appears to boost Treg cells and Th1 cells in lymph nodes, though it doesn’t influence Treg cell development in the thymus.
Article Abstract
Cordyceps sinensis is a widely used Chinese traditional herb with a long history. In China C. sinensis is usually applied in the treatment of respiratory diseases, however, the efficacy of C. sinensis still lacks experimental evidence. Type I diabetes is a multi-factor related autoimmune disease caused by cellular-mediated destruction of insulin-producing pancreatic beta cells in the islets in human. We tested C. sinensis for its ability to work as an immune modulator in NOD mice, an animal model which mimicks the progression of type I diabetes in humans and found that treatment with C. sinensis extract could slow down disease development in NOD mice. Further research also suggested that treatment with C. sinensis extract increased the frequency of Treg cells and IFN-gama producing Th1 cells in peripheral lymph nodes. However, C. sinensis has no effect on the natural Treg cell differentiation in thymus.
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