Purpose: To investigate the prognostic impact of the Charlson comorbidity index (CCI) on either cancer-specific mortality (CSM) or other-cause mortality (OCM) according to age in patients with prostate cancer (PC) who underwent radical prostatectomy (RP).
Methods: Data from 336 patients who underwent RP for PC between 1992 and 2005 were analyzed. Variables, including the preoperative prostate-specific antigen (PSA), prostate volume, clinical stage, and pathologic stage, were compared across age groups (<65 or ≥65 years old). Preexisting comorbidities were evaluated by the CCI, and patients were classified into two CCI score categories (0 or ≥1).
Results: The median (interquartile range) follow-up period was 96 (85-121) months. Subjects were divided into two subgroups according to age: <65 years (n = 151) or ≥65 years (n = 185). There was no significant difference in PSA, biopsy Gleason sum, body mass index, pathologic stage, or CCI between the two age groups. OCM was significantly associated with the CCI score (P = 0.011). Cumulative incidence estimates obtained from competing risk regression analysis indicated that CCI was not associated with CSM (P = 0.795) or OCM (P = 0.123) in the ≥65-year group. However, in men <65 years, cumulative incidence estimates for OCM were significantly associated with CCI (P = 0.036).
Conclusions: CCI was independently associated with OCM after RP, but only in men <65 years old. CCI was not associated with CSM in either age group. Accordingly, a thorough evaluation of patient's comorbidities is mandatory when considering aggressive surgical treatment, especially in relatively young patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1245/s10434-013-3326-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Neuropsychiatric disorders including depression, insomnia, epilepsy, schizophrenia, and attention-deficit and hyperactivity disorder (ADHD) have been associated with a neurodegenerative process and linked to increased risk for Alzheimer's Disease (AD). Because of the shared biological mechanisms of AD and neuropsychiatric disorders, we hypothesized that pharmacologic treatment for neuropsychiatric disorders could impact the risk for AD. CNS drugs that are first-line therapies for neuropsychiatric disorders (including antidepressants, sedatives, anticonvulsants, antipsychotics, and stimulants) were investigated for impact on AD incidence.
View Article and Find Full Text PDFComorbid conditions and survival among Black women with ovarian cancer.
Cancer
January 2025
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
Background: Black women with epithelial ovarian cancer (EOC) have worse survival and a higher burden of comorbid conditions compared with other racial groups. This study examines the association of comorbid conditions and medication use for these conditions with survival among Black women with EOC.
Methods: In a prospective study of 592 Black women with EOC, the Charlson comorbidity index (CCI) based on self-reported data, three cardiometabolic comorbidities (type 2 diabetes, hypertension, and hyperlipidemia), and medication use for each cardiometabolic comorbidity were evaluated.
Impact of Multimorbidity Burden on Mortality Risk among Colon Cancer Survivors.
J Cancer
January 2025
Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
Article Synopsis
- The study examined the risk of multiple chronic conditions (multimorbidity) among colon cancer survivors using data from Taiwan's cancer registry.
- It found that the majority of the 13,209 survivors had no comorbidities, while a smaller percentage had mild or severe conditions.
- Higher scores on the Charlson Comorbidity Index (CCI) were linked to increased mortality risk, highlighting the need for better comorbidity management to enhance survival in patients, especially those with severe conditions.
Interstitial lung diseases with concomitant lung cancer: a data mining approach revealing a complex condition with gender- and immune-associated specific implications.
Front Oncol
December 2024
Department of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, Italy.
Article Synopsis
- Interstitial lung diseases (ILDs), especially idiopathic pulmonary fibrosis (IPF), lead to severe lung scarring, increased lung cancer risk, and poor patient outcomes, with a high incidence of mortality.
- A study analyzed a cohort of 73 ILD patients with lung cancer, primarily focusing on 55 with comprehensive data, discovering significant predictors such as age at diagnosis, comorbidities, and gender differences in survival rates.
- Key findings indicate that most tumors were adenocarcinomas, early detection is common, and factors like surgical treatment and autoantibody presence are important for predicting patient survival outcomes in those with IPF-associated lung cancer.
Incidence of Potentially Inappropriate Prescribing: Longitudinal Investigation of Outpatient EHR Prescriptions.
J Am Geriatr Soc
December 2024
Department of Pharmacy and Therapeutics, School of Pharmacy, Pittsburgh, Pennsylvania, USA.
Importance: The incidence of potentially inappropriate medication (PIM) prescribing among older adults is not as well studied as its prevalence. Estimates of factors associated with PIM incidence, such as patient age, sex, race-ethnicity, medication subsidy support, and comorbidity, are also limited.
Objective: To estimate the incidence of PIM prescribing in older adult outpatients, as well as the incidence and predictors for each PIM class, in a large outpatient electronic health records (EHR) cohort.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!