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Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review.

Cancer Rep (Hoboken)

January 2025

Department of Dermatology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.

Background: Glomus tumors are rare, benign mesenchymal neoplasms predominantly located in subungual regions of the extremities. Their occurrence in the mandibular region is exceptionally uncommon, presenting unique diagnostic challenges. Only a limited number of submandibular glomus tumors have been documented, leaving their presentation and management largely underexplored.

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Juxtaglomerular cell tumor (JxGCT) is a rare type of renal neoplasm demonstrating morphologic overlap with some mesenchymal tumors such as glomus tumor (GT) and solitary fibrous tumor (SFT). Its oncogenic drivers remain elusive, and only a few cases have been analyzed with modern molecular techniques. In prior studies, loss of chromosomes 9 and 11 appeared to be recurrent.

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Introduction: The ZAP-X® Gyroscopic Radiosurgery System (ZAP Surgical Systems, Inc., San Carlos, CA, USA) is expected to be a highly accurate next-generation treatment system that enables gyro-stereotactic irradiation of intracranial lesions. In this study, we report the initial treatment course using ZAP-X for intracranial lesions that recurred after Gamma Knife (GK) treatment.

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Article Synopsis
  • * Imaging tests revealed a significant mass in the left bladder and a nonfunctional right kidney, leading to surgical removal of both the kidney and part of the bladder.
  • * The final diagnosis was a bladder glomus tumor, and the patient remains healthy with no signs of recurrence after 15 months, underscoring the need for urologists to consider glomus tumors in their diagnostic process.
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Gastric glomus tumor with uncertain malignant potential: case report of a rare cause of upper gastrointestinal bleeding.

World J Surg Oncol

November 2024

Department of Surgery, Albert Szent-Györgyi Health Center, University of Szeged, Semmelweis Street 8, Szeged, H-6725, Hungary.

Article Synopsis
  • Glomus tumors (GTs) are mostly benign neoplasms found in the upper gastrointestinal tract, making malignant cases exceptionally rare, which complicates diagnosis due to similarities with other tumors.
  • A 52-year-old male patient experienced fatigue and bleeding, leading to the discovery of a gastric GT after multiple examinations, with histopathology confirming it as a potentially malignant tumor.
  • The case highlights the need for detailed histopathological and molecular analysis for correct diagnosis and stresses the importance of surgical intervention and long-term monitoring for recurrence and malignancy risks.
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