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| http://dx.doi.org/10.4161/cc.26875 | DOI Listing |
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A new species of direct-developing frog of the genus Eleutherodactylus (Anura: Eleutherodactylidae) from Tamaulipas, Mexico.
Zootaxa
June 2024
Departamento de Zoología; Instituto de Biología; Universidad Nacional Autónoma de México; A.P. 70-153; 04510; Ciudad de Mexico; México.
The number of species of the subgenus Syrrhophus, genus Eleutherodactylus has increased rapidly in the last eight years, due to recent taxonomic studies. This subgenus of direct-developing frogs is well represented in Mexico, which harbors more than 90% of the species richness reported for the subgenus. In this study, we describe one new species, Eleutherodactylus (Syrrhophus) coelum sp.
View Article and Find Full Text PDFBeginning at the ends: telomere and telomere-based cancer therapeutics.
Mol Genet Genomics
December 2024
Department of Medical Genetics, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.
Telomeres, which are situated at the terminal ends of chromosomes, undergo a reduction in length with each cellular division, ultimately reaching a critical threshold that triggers cellular senescence. Cancer cells circumvent this senescence by utilizing telomere maintenance mechanisms (TMMs) that grant them a form of immortality. These mechanisms can be categorized into two primary processes: the reactivation of telomerase reverse transcriptase and the alternative lengthening of telomeres (ALT) pathway, which is dependent on homologous recombination (HR).
View Article and Find Full Text PDFInsights into early animal evolution from the genome of the xenacoelomorph worm .
Elife
August 2024
Center for Life's Origins and Evolution, Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
Article Synopsis
- The evolutionary origin of Bilateria is unclear, but similarities between cnidarian-like larvae and simple flatworms suggest a connection, linking Xenacoelomorpha as a potential early branch of Bilateria.
- This study focuses on assembling and analyzing the genome of a marine xenacoelomorph, discovering it has a genome size of ~111 Mbp with characteristics similar to other bilaterians.
- The findings indicate that despite its simple body plan, the xenacoelomorph has a complex genome and retains many features typical of bilaterians, challenging previous assumptions about its evolutionary simplicity.
Expression, not sequence, distinguishes miR-238 from its miR-239ab sister miRNAs in promoting longevity in Caenorhabditis elegans.
PLoS Genet
November 2023
Molecular Biology Department, School of Biological Sciences, University of California, San Diego, La Jolla, California, United States of America.
MicroRNAs (miRNAs) regulate gene expression by base-pairing to target sequences in messenger RNAs (mRNAs) and recruiting factors that induce translational repression and mRNA decay. In animals, nucleotides 2-8 at the 5' end of the miRNA, called the seed region, are often necessary and sometimes sufficient for functional target interactions. MiRNAs that contain identical seed sequences are grouped into families where individual members have the potential to share targets and act redundantly.
View Article and Find Full Text PDFPhylogenomic Analysis of micro-RNA Involved in Juvenile to Flowering-Stage Transition in Photophilic Rice and Its Sister Species.
Cells
May 2023
ICAR-National Institute for Plant Biotechnology, Pusa Campus, New Delhi 110012, India.
Vegetative to reproductive phase transition in phototropic plants is an important developmental process and is sequentially mediated by the expression of micro-RNA . To obtain insight into the evolution, adaptation, and function of in photophilic rice and its wild relatives, we analyzed the genescape of a 100 kb segment harboring homologs from 11 genomes. The expression analysis of revealed its incremental accumulation from the 2-leaf to 10-leaf stage, with maximum expression coinciding with the flag-leaf stage in rice.
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