Background: Driving a car is a complex instrumental activity of daily living and driving performance is very sensitive to cognitive impairment. The assessment of driving-relevant cognition in older drivers is challenging and requires reliable and valid tests with good sensitivity and specificity to predict safe driving. Driving simulators can be used to test fitness to drive. Several studies have found strong correlation between driving simulator performance and on-the-road driving. However, access to driving simulators is restricted to specialists and simulators are too expensive, large, and complex to allow easy access to older drivers or physicians advising them. An easily accessible, Web-based, cognitive screening test could offer a solution to this problem. The World Wide Web allows easy dissemination of the test software and implementation of the scoring algorithm on a central server, allowing generation of a dynamically growing database with normative values and ensures that all users have access to the same up-to-date normative values.
Objective: In this pilot study, we present the novel Web-based Bern Cognitive Screening Test (wBCST) and investigate whether it can predict poor simulated driving performance in healthy and cognitive-impaired participants.
Methods: The wBCST performance and simulated driving performance have been analyzed in 26 healthy younger and 44 healthy older participants as well as in 10 older participants with cognitive impairment. Correlations between the two tests were calculated. Also, simulated driving performance was used to group the participants into good performers (n=70) and poor performers (n=10). A receiver-operating characteristic analysis was calculated to determine sensitivity and specificity of the wBCST in predicting simulated driving performance.
Results: The mean wBCST score of the participants with poor simulated driving performance was reduced by 52%, compared to participants with good simulated driving performance (P<.001). The area under the receiver-operating characteristic curve was 0.80 with a 95% confidence interval 0.68-0.92.
Conclusions: When selecting a 75% test score as the cutoff, the novel test has 83% sensitivity, 70% specificity, and 81% efficiency, which are good values for a screening test. Overall, in this pilot study, the novel Web-based computer test appears to be a promising tool for supporting clinicians in fitness-to-drive assessments of older drivers. The Web-based distribution and scoring on a central computer will facilitate further evaluation of the novel test setup. We expect that in the near future, Web-based computer tests will become a valid and reliable tool for clinicians, for example, when assessing fitness to drive in older drivers.
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http://dx.doi.org/10.2196/jmir.2943 | DOI Listing |
Sci Rep
December 2024
School of Automation Science and Electrical Engineering, Beihang University, Beijing, 100191, China.
A novel adaptive model-based motion control method for multi-UAV communication relay is proposed, which aims at improving the networks connectivity and the communications performance among a fleet of ground unmanned vehicles. The method addresses the challenge of relay UAVs motion control through joint consideration with unknown multi-user mobility, environmental effects on channel characteristics, unavailable angle-of-arrival data of received signals, and coordination among multiple UAVs. The method consists of two parts: (1) Network connectivity is constructed and communication performance index is defined using the minimum spanning tree in graph theory, which considers both the communication link between ground node and UAV, and the communication link between ground nodes.
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December 2024
College of Geography and Environment, Shandong Normal University, Jinan, 250358, China.
The urban agglomeration represents the predominant form of new urbanisation, yet the evolution of its internal spatial structure exhibits pronounced spatial and temporal heterogeneity. This study concentrates on the Bohai Rim urban agglomeration, one of three major urban agglomerations in China, which has received comparatively limited research attention but has also undergone substantial urbanisation. Therefore, we reassessed and explored the spatial-temporal evolution of the spatial structure of urban expansion using Exploratory Spatiotemporal Data Analysis (ESTDA), and summarized the driving mechanisms using Geographically and Temporally Weighted Regression (GTWR).
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December 2024
School of Mechanical Engineering, Changzhou Institute of Technology, Changzhou, 213032, China.
Traditional sprayers are limited to applying spray mixture solely to the upper surfaces of crops. To overcome this limitation, a variable angle spraying machine (VASM) was designed using a linkage system. This machine enables the adjustment of both the spray position and angle through a single input signal, facilitating multi-directional spraying from the top to the bottom of crops.
View Article and Find Full Text PDFJ Pharm Sci
December 2024
Certara UK Ltd., Certara Predictive Technologies Division, 1 Concourse Way, Level 2-Acero, Sheffield, S1 2BJ, United Kingdom. Electronic address:
Predicting steady-state volume of distribution (V) is a key component of pharmacokinetic predictions and often guided using preclinical data. However, when bottom-up prediction from physiologically-based pharmacokinetic (PBPK) models and observed V misalign in preclinical species, or predicted V from different models varies significantly, no consensus exists for selecting models or preclinical species to improve the prediction. Through systematic analysis of V prediction across rat, dog, monkey, and human, using common methods, a practical strategy for predicting human V, with or without integration of preclinical PK information is warranted.
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December 2024
School of Psychological Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.
Investigations into whether playing action video games (AVGs) benefit other tasks, such as driving, have traditionally focused on gaming experience (i.e., hours played).
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