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The dynamin inhibitor, dynasore, prevents zoledronate-induced viability loss in human gingival fibroblasts by partially blocking zoledronate uptake and inhibiting endosomal acidification.
J Appl Oral Sci
October 2024
Indiana Wesleyan University, Division of Natural Sciences, Indiana, United States.
Article Synopsis
- The study aimed to explore the effectiveness of phosphonoformic acid (PFA) and Dynasore in preventing medication-related osteonecrosis of the jaw by blocking bisphosphonates' entry into human gingival fibroblasts (HGFs).
- The researchers found that while PFA did not protect HGFs from the harmful effects of zoledronate (ZOL), Dynasore successfully prevented cell death when exposed to ZOL and inhibited the macropinocytosis process.
- Overall results indicated that Dynasore was effective in blocking ZOL entry and preventing endosomal acidification, suggesting it could be a potential treatment option for managing medication-related osteonecrosis of the jaw.
The potential role of SNHG16/ miRNA-146a/ TRAF6 signaling pathway in the protective effect of zoledronate against colorectal cancer and associated osteoporosis in mouse model.
Int Immunopharmacol
May 2024
Department of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Electronic address:
Bone fracture as a consequence of colorectal cancer (CRC) and associated osteoporosis (OP) is considered a risk factor for increasing the mortality rate among CRC patients. SNHG16/ miRNA-146a/ TRAF6 signaling pathway is a substantial contributor to neoplastic evolution, progression, and metastasis. Here, we investigated the effect of zoledronate (ZOL) on the growth of CRC and associated OP in a mouse model.
View Article and Find Full Text PDFSilver-Sulfamethazine-Conjugated β-Cyclodextrin/Dextran-Coated Magnetic Nanoparticles for Pathogen Inhibition.
Nanomaterials (Basel)
February 2024
Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 00 Prague 6, Czech Republic.
In the fight against antibiotic resistance, which is rising to dangerously high levels worldwide, new strategies based on antibiotic-conjugated biocompatible polymers bound to magnetic nanoparticles that allow the drug to be manipulated and delivered to a specific target are being proposed. Here, we report the direct surface engineering of nontoxic iron oxide nanoparticles (IONs) using biocompatible dextran (Dex) covalently linked to β-cyclodextrin (β-CD) with the ability to form non-covalent complexes with silver-sulfamethazine (SMT-Ag). To achieve a good interaction of β-CD-modified dextran with the surface of the nanoparticles, it was functionalized with diphosphonic acid (DPA) that provides strong binding to Fe atoms.
View Article and Find Full Text PDFDepletion of muscularis macrophages ameliorates inflammation-driven dysmotility in murine colitis model.
Sci Rep
December 2023
Department of Anatomy, Histology and Embryology, Semmelweis University, Tuzolto St. 58, Budapest, 1094, Hungary.
Previously, the presence of a blood-myenteric plexus barrier and its disruption was reported in experimentally induced colitis via a macrophage-dependent process. The aim of this study is to reveal how myenteric barrier disruption and subsequent neuronal injury affects gut motility in vivo in a murine colitis model. We induced colitis with dextran sulfate sodium (DSS), with the co-administration of liposome-encapsulated clodronate (L-clodronate) to simultaneously deplete blood monocytes contributing to macrophage infiltration in the inflamed muscularis of experimental mice.
View Article and Find Full Text PDFMussel-Inspired Bisphosphonated Injectable Nanocomposite Hydrogels with Adhesive, Self-Healing, and Osteogenic Properties for Bone Regeneration.
ACS Appl Mater Interfaces
July 2021
Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, PR China.
Injectable hydrogels have received much attention because of the advantages of simulation of the natural extracellular matrix, microinvasive implantation, and filling and repairing of complex shape defects. Yet, for bone repair, the current injectable hydrogels have shown significant limitations such as the lack of tissue adhesion, deficiency of self-healing ability, and absence of osteogenic activity. Herein, a strategy to construct mussel-inspired bisphosphonated injectable nanocomposite hydrogels with adhesive, self-healing, and osteogenic properties is developed.
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