CPAF is a conserved and secreted protease from obligate intracellular bacteria of the order Chlamydiales. Recently, it was demonstrated that most of its host targets are an artifact of inaccurate methods. This review aims to summarize key features of CPAF and propose new approaches for evaluating its role in chlamydial pathogenesis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320975 | PMC |
http://dx.doi.org/10.1016/j.micinf.2013.09.008 | DOI Listing |
Stress Health
February 2025
Department of Psychology, The University of British Columbia, Vancouver, Canada.
The Hamas-led terrorist attacks in Israel on October 7, 2023, were an inflection point that spurred a global rise in antisemitism. College and university campuses were particularly affected. Given the adverse impacts of prejudice and discrimination for mental health and the dearth of research on psychosocial effects of antisemitism, examining stress, coping, and mental health among Jewish students within this context is crucial.
View Article and Find Full Text PDFInsulin degrading enzyme (IDE) is a dimeric 110 kDa M16A zinc metalloprotease that degrades amyloidogenic peptides diverse in shape and sequence, including insulin, amylin, and amyloid-β, to prevent toxic amyloid fibril formation. IDE has a hollow catalytic chamber formed by four homologous subdomains organized into two ∼55 kDa N- and C-domains (IDE-N and IDE-C, respectively), in which peptides bind, unfold, and are repositioned for proteolysis. IDE is known to transition between a closed state, poised for catalysis, and an open state, able to release cleavage products and bind new substrate.
View Article and Find Full Text PDFExpert Rev Med Devices
January 2025
Division of Gastroenterology, P.D Hinduja Hospital, Mumbai, India.
Introduction: Wearables are electronic devices worn on the body to collect health data. These devices, like smartwatches and patches, use sensors to gather information on various health parameters. This review highlights current use and the potential benefit of wearable technology in patients with inflammatory bowel disease (IBD).
View Article and Find Full Text PDFSensors (Basel)
December 2024
Institute for Production Technology and Systems (IPTS), Leuphana Universität Lüneburg, 21335 Lüneburg, Germany.
An intelligent transportation system (ITS) offers commercial and personal movement through the smart city (SC) communication paradigms with hassle-free information sharing. ITS designs and architectures have improved via information and communication technologies in recent years. The information shared through the communication medium in SCs is exposed to adversary risk, resulting in privacy issues.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Political Science, University of Chicago, Chicago, IL 60637.
Among the most pressing problems societies face today are economic inequality and the erosion of democratic norms and institutions. In fact the two problems-inequality and democratic erosion-are linked. In a large cross-national statistical study of risk factors for democratic erosion, we establish that economic inequality is one of the strongest predictors of where and when democracy erodes.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!