A path forward for the chlamydial virulence factor CPAF.

Microbes Infect

Department of Microbiology and Immunology, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA.

Published: December 2013

CPAF is a conserved and secreted protease from obligate intracellular bacteria of the order Chlamydiales. Recently, it was demonstrated that most of its host targets are an artifact of inaccurate methods. This review aims to summarize key features of CPAF and propose new approaches for evaluating its role in chlamydial pathogenesis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320975PMC
http://dx.doi.org/10.1016/j.micinf.2013.09.008DOI Listing

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