The aim of this study was to assess the ability of some vehicles (emulsion and emulgel), containing hydrogenated lecithin as penetration enhancer, in increasing the percutaneous absorption of the two model compounds dipotassium glycyrrhizinate (DG) and stearyl glycyrrhetinate (SG). Furthermore SG-loaded solid lipid nanoparticles (SLNs) were prepared and the effect of this vehicle on SG permeation profile was evaluated as well. Percutaneous absorption has been studied in vitro, using excised human skin membranes (i.e., stratum corneum epidermis or [SCE]), and in vivo, determining their anti-inflammatory activity. From the results obtained, the use of both penetration enhancers and SLNs resulted in being valid tools to optimize the topical delivery of DG and SG. Soy lecithin guaranteed an increase in the percutaneous absorption of the two activities and a rapid anti-inflammatory effect in in vivo experiments, whereas SLNs produced an interesting delayed and sustained release of SG.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Alchemy in Nature: The Role of Extract Choice in Crafting Potent Anticancer Metal Nanoparticles.
ACS Appl Mater Interfaces
January 2025
Department of Chemistry, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab Emirates.
Phyto-nanotechnology provides an eco-friendly approach for synthesizing biocompatible metal nanoparticles (NPs) with therapeutic potential. (LI) has been historically valued for its diverse medicinal applications, especially its exceptional biological potency against various skin diseases, attributed to its rich abundance of bioactive compounds. Therefore, herein, plant-based iron and zinc NPs were biofabricated via sustainable and simple methods, using crude extracts of the aerial parts of LI as reducing, coating, and stabilizing agents.
View Article and Find Full Text PDFSuperabsorbent wound dressings for the management of highly exuding wounds: a literature review.
J Wound Care
January 2025
Coloplast A/S, Holtedam 1, Humlebæk, Denmark.
Exudate management is essential for creating a moist wound environment that promotes optimal healing, especially in highly exuding wounds, where choosing an appropriate wound dressing to handle high volumes of exudate is a key part of the wound management strategy. Superabsorbent wound dressings (SWDs) have been designed to absorb and retain large amounts of exudate. Thus, they are advocated for management of wounds with moderate-to-high levels of exudate to reduce the risk of leakage and damage to the periwound skin.
View Article and Find Full Text PDFDesign and Characterization of Novel Polymeric Hydrogels with Protein Carriers for Biomedical Use.
Int J Mol Sci
December 2024
Department of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawla II Av., 31-864 Krakow, Poland.
Hydrogels are three-dimensional polymeric matrices capable of absorbing significant amounts of water or biological fluids, making them promising candidates for biomedical applications such as drug delivery and wound healing. In this study, novel hydrogels were synthesized using a photopolymerization method and modified with cisplatin-loaded protein carriers, as well as natural extracts of nettle () and chamomile ( L.).
View Article and Find Full Text PDFInjectable Gelatin-Palmitoyl-GDPH Hydrogels as Bioinks for Future Cutaneous Regeneration: Physicochemical Characterization and Cytotoxicity Assessment.
Polymers (Basel)
December 2024
Department of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Tissue engineering and regenerative medicine have made significant breakthroughs in creating complex three-dimensional (3D) constructs that mimic human tissues. This progress is largely driven by the development of hydrogels, which enable the precise arrangement of biomaterials and cells to form structures resembling native tissues. Gelatin-based bioinks are widely used in wound healing due to their excellent biocompatibility, biodegradability, non-toxicity, and ability to accelerate extracellular matrix formation.
View Article and Find Full Text PDFAre We Ready to Measure Skin Permeation of Modern Antiaging GHK-Cu Tripeptide Encapsulated in Liposomes?
Molecules
January 2025
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego St. 3, 00-664 Warsaw, Poland.
Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers of the skin, and this shortcoming significantly reduces their efficacy. One such CAC that occurs naturally in the human body and displays many beneficial properties (via reducing fine lines and wrinkles, tightening skin, improving its elasticity, etc.) is the glycyl-L-histidyl-L-lysine tripeptide complex of copper (GHK-Cu).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!