A rare, badly known diffuse pulmonary lesion--multifocal hyalinizing intravascular "bronchiolo-alveolar" tumour in a woman of 22, is described. The lesion was revealed at fluorography, diagnosed by means of mediastinopleuroscopy, in lung biopsy; there were no clinical manifestations. A hyalinized compact and branching node, poor in cells, intruding at the periphery into the alveolar septa in the form of micropolyps was found histologically.
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Cureus
July 2024
Dermatopathology Section, Regional Medical Laboratory, Inc., Tulsa, USA.
Schwannomas (SCHs) are benign neural tumors originating from Schwann cells of the peripheral nerve sheaths. These neoplasms typically exhibit hyalinized vessels with impaired vascular permeability; however, angioma-like features are rare. We report an intriguing case of a cutaneous SCH with unusual vascular changes in a 60-year-old female who presented with a tender nodular lesion on her lower back.
View Article and Find Full Text PDFInt J Surg Pathol
April 2024
Department of Pathology and Laboratory Medicine, North Shore University Hospital and Long Island Jewish Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Greenvale, NY, USA.
Papillary hemangioma is a novel variant of intravascular hemangioma. It is more common in adults and has a male predominance. Most tumors reported so far are solitary and cutaneous.
View Article and Find Full Text PDFBiomed Pharmacother
July 2023
Department of Stem Cells and Regenerative Medicine, College of Basic Medical Science, China Medical University, Shenyang 110122, China. Electronic address:
Lifeways of worldwide people have changed dramatically amid the coronavirus disease 2019 (COVID-19) pandemic, and public health is at stake currently. In the early stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, fibrinolytic system is mostly inhibited, which is responsible for the development of hypofibrinolysis, promoting disseminated intravascular coagulation, hyaline membrane formation, and pulmonary edema. Whereas the common feature and risk factor at advanced stage is a large amount of fibrin degradation products, including D-dimer, the characteristic of hyperfibrinolysis.
View Article and Find Full Text PDFTransl Stroke Res
June 2024
Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Translational Medicine for Brain Critical Diseases, Nanjing University, Nanjing, 210008, China.
Cerebral small vessel disease (CSVD) is the most common progressive vascular disease that causes vascular dementia. Aging and hypertension are major contributors to CSVD, but the pathophysiological mechanism remains unclear, mainly due to the lack of an ideal animal model. Our previous study revealed that vascular smooth muscle cell (VSMC)-specific myosin phosphatase target subunit 1 (MYPT1) knockout (MYPT1) leads to constant hypertension, prompting us to explore whether hypertensive MYPT1 mice can be considered a novel CSVD animal model.
View Article and Find Full Text PDFCureus
September 2022
Infectious Disease, University of Florida College of Medicine- Jacksonville, Jacksonville, USA.
Although rare in the U.S invasive Fusariosis (IF) is increasingly being recognized as a cause of severe invasive fungal disease in patients with neutropenia in the setting of hematologic malignancy and hematopoietic stem cell transplants (HSCT). IF in these patients is associated with high mortality, moreover there are no guidelines on effective therapy, thus early diagnosis and involvement of an expert with experience in treating Fusariosis are imperative.
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