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Mechanisms of hemostimulating effect of Aconitum baicalense diterpene alkaloids. | LitMetric
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Mechanisms of hemostimulating effect of Aconitum baicalense diterpene alkaloids.

G N Zyuz'kov V V Zhdanov L A Miroshnichenko E V Udut E V Simanina L A Stavrova V I Agafonov A V Chaikovskiy M Yu Minakova T N Povet'eva N I Suslov A V Krapivin Yu V Nesterova A A Semenov D V Reykhart A M Dygai

Bull Exp Biol Med

Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk; National Research Irkutsk State Technical University, Russia.

Published: July 2013

A mixture of diterpene alkaloids of Aconitum baicalense exhibited pronounced regenerative hemostimulating properties on the model of cytostatic myelosuppression. The therapeutic effect is based on activation of hemopoietic progenitor cells against the background of increased feeder capacity of stromal compartment of the hemopoiesis-inducing microenvironment and decreased count of mesenchymal stem cells in the bone marrow.

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http://dx.doi.org/10.1007/s10517-013-2151-zDOI Listing

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